Facebook Twitter Instagram Youtube
Donate
stemmacolore

LINE 1 – experimental oncology

Homepage
LINE 1 – experimental oncology

Supervisor

Dr. Stefano Indraccolo

Description

This research line involves the study of the genetic and molecular mechanisms underlying tumor heterogeneity and of the complex relationship between the tumor and the microenvironment, in both human tumors and preclinical models. Such research will lead to the implementation of molecular diagnostic approaches and new treatments into clinical practice, which will provide real-time benefits for cancer patients.

Background

Experimental oncology has historically been a key think tank for the conception of cancer biology models; it is also the starting point for the development of innovative cancer therapies that, over the past two decades, have become available to a wider range of cancer patients. Examples include molecular target therapies for “actionable” genes and therapies that modulate the tumor microenvironment, such as antiangiogenic therapy and immunotherapy. One of the main challenges of this research line is to combine pre-clinical observations with those obtained from clinical experience and translate this wealth of knowledge intodiagnostic and therapeutic improvements.

Rationale

One of the emerging aspects at the cross level in cancer research is the so-called tumor heterogeneity, which affects both the tumor component and the stroma, and needs to be better characterized in order to provide state of the art therapeutic options. The study of this phenomenon, with cutting-edge technologies at multiple levels (genetic, epigenetic, phenotypic), is essential for the optimization of personalized therapy with molecular target drugs, the understanding of resistance mechanisms, and for the accurate prediction of the genetic risk of cancer.

Global goals

  1. identification of new genetic alterations of pathogenetic and therapeutic relevance;
  2. characterization of tumor heterogeneity at the level of individual tumor cells;
  3. identification of metabolic and transcriptomic profiles of neoplastic cells;
  4. development of mouse models of tumor for the experimentation of innovative therapies.

Expected results

During the three-year period, completion of the IRCCS technological update and a strengthening of translational studies are expected and – starting from a better characterization of tumor biology – will lead to significant results both in terms of identification and validation of new prognostic or predictive molecular markers. Moreover, through the pre-clinical validation of new therapeutic approaches in clinically relevant mouse models, it will be possible to identify pharmacological strategies that –once transferred into the clinical setting – can lead to the improvement of current therapeutic results.

Top 15 pubblicazioni Linea 1 anno 2020
TitoloAutori/AutriciRivistaIF grezzo
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genesInvestigators ABCTB, Collaborators GEMO Study, Collaborators EMBRACE, Investigators KConFab, Investigators HEBON, Fachal Laura, Aschard Hugues, Beesley Jonathan, Barnes Daniel R., Allen Jamie, Kar Siddhartha, Pooley Karen A., Dennis Joe, Michailidou Kyriaki, Turman Constance, Soucy Penny, Lemaçon Audrey, Lush Michael, Tyrer Jonathan P., Ghoussaini Maya, Marjaneh Mahdi Moradi, Jiang Xia, Aittomäki Kristiina, Alonso M. Rosario, Andrulis Irene L., Anton-Culver Hoda, Antonenkova Natalia N., Arason Adalgeir, Arndt Volker, Aronson Kristan J., Arun Banu K., Auber Bernd, Auer Paul L., Azzollini Jacopo, Balmaña Judith, Barkardottir Rosa B., Barrowdale Daniel, Beeghly-Fadiel Alicia, Benitez Javier, Bermisheva Marina, Bia¿kowska Katarzyna, Blanco Amie M., Blomqvist Carl, Blot William, Bogdanova Natalia V., Bojesen Stig E., Bolla Manjeet K., Bonanni Bernardo, Borg Ake, Manoukian Siranoush, Montagna Marco, Peissel Bernard, Radice Paolo, Viel AlessandraNATURE GENETICS27.605
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibilityLandi MT, Menin Chiara, Elefanti Lisa, De Nicolo Arcangela, Q-MEGA and QTWIN Investigators; ATHENS Melanoma Study Group, GenoMEL ConsortiumNATURE GENETICS27.605
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analysesKConFab Investigators Gruppo, Zhang Haoyu, Ahearn Thomas U, Lecarpentier Julie, Barnes Daniel, Beesley Jonathan, Qi Guanghao, Jiang Xia, O’Mara Tracy A, Zhao Ni, Bolla Manjeet K, Dunning Alison M, Dennis Joe, Wang Qin, Ful Zumuruda Abu, Aittomäki Kristiina, Andrulis Irene L, Anton-Culver Hoda, Arndt Volker, Aronson Kristan J, Arun Banu K, Auer Paul L, Azzollini Jacopo, Barrowdale Daniel, Becher Heiko, Beckmann Matthias W, Behrens Sabine, Benitez Javier, Bermisheva Marina, Bialkowska Katarzyna, Blanco Ana, Blomqvist Carl, Bogdanova Natalia V, Bojesen Stig E, Bonanni Bernardo, Bondavalli Davide, Borg Ake, Brauch Hiltrud, Brenner Hermann, Briceno Ignacio, Broeks Annegien, Brucker Sara Y, Brüning Thomas, Burwinkel Barbara, Buys Saundra S, Calvello Mariarosaria, Manoukian Siranoush, Matricardi Laura, Montagna Marco, Peissel Bernard, Radice PaoloNATURE GENETICS27.605
Characterization of the Cancer Spectrum in Men with Germline BRCA1 and BRCA2 Pathogenic Variants:Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)BRCA1/2 CIMBA – Consortium of Investigators of Modifiers of, Silvestri Valentina, Leslie Goska, Barnes Daniel R., Agnarsson Bjarni A., Aittomäki Kristiina, Alducci Elisa, Andrulis Irene L., Barkardottir Rosa B., Barroso Alicia, Barrowdale Daniel, Benitez Javier, Bonanni Bernardo, Borg Ake, Buys Saundra S., Caldés Trinidad, Caligo Maria A., Capalbo Carlo, Campbell Ian, Chung Wendy K., Claes Kathleen B.M., Colonna Sarah V., Cortesi Laura, Couch Fergus J., De La Hoya Miguel, Diez Orland, Ding Yuan Chun, Domchek Susan, Easton Douglas F., Ejlertsen Bent, Engel Christoph, Evans D. Gareth, Feliubadalò Lidia, Foretova Lenka, Fostira Florentia, Géczi Lajos, Gerdes Anne Marie, Glendon Gord, Godwin Andrew K., Goldgar David E., Hahnen Eric, Hogervorst Frans B.L., Hopper John L., Hulick Peter J., Isaacs Claudine, Izquierdo Angel, Manoukian Siranoush, Montagna Marco, Moserle Lidia, Radice Paolo, Viel AlessandraJAMA ONCOLOGY24.799
p16/ki67 and E6/E7 mRNA accuracy and prognostic value in triaging HPV DNA-positive womenGroup NTCC2 Working, Rossi Paolo Giorgi, Carozzi Francesca, Ronco Guglielmo, Allia Elena, Bisanzi Simonetta, Gillio-Tos Anna, De Marco Laura, Rizzolo Raffaella, Gustinucci Daniela, Del Mistro Annarosa, Frayle Helena, Confortini Massimo, Iossa Anna, Cesarini Elena, Bulletti Simonetta, Passamonti Basilio, Gori Silvia, Toniolo Laura, Barca Alessandra, Bonvicini Laura, Mancuso Pamela, Venturelli Francesco, Benevolo MariaJOURNAL OF THE NATIONAL CANCER INSTITUTE11.577
Periostin and Epithelial-Mesenchymal Transition Score as Novel Prognostic Markers for Leiomyosarcoma, Myxofibrosarcoma, and Undifferentiated Pleomorphic SarcomaPiano Maria Assunta, Brunello Antonella, Cappellesso R, Del Bianco Paola, Mattiolo A, Fritegotto C, Montini B, ZAMUNER CAROLINA, Del Fiore Santo Paolo, Rastrelli Marco, Sommariva Antonio, De Salvo Gian Luca, Montesco MC, Rossi Carlo Riccardo, zagonel vittorina, Calabro’ Maria LuisaCLINICAL CANCER RESEARCH10.107
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variantsDaniel R Barnes, Matti A Rookus, Montagna Marco, Tognazzo Silvia, Antonis C Antoniou, Consortium of Investigators of Modifiers of BRCA and BRCA2GENETICS IN MEDICINE8.904
Kidney cancer PDOXs reveal patient-specific pro-malignant effects of antiangiogenics and its molecular traitsMoserle Lidia, Pons Roser, Martínez-Lozano Mar, Jiménez-Valerio Gabriela A, Vidal August, Suárez Cristina, Trilla Enrique, Jiménez José, de Torres Inés, Carles Joan, Senserrich Jordi, Aguilar Susana, Palomero Luis, Amadori Alberto, Casanovas OriolEMBO MOLECULAR MEDICINE8.821
Cross-talk between GLI transcription factors and FOXC1 promotes T-cell acute lymphoblastic leukemia disseminationTosello Valeria, Bongiovanni Deborah, Liu Jingjing, Pan Qingfei, Yan Koon kiu, Saccomani Valentina, Van Trimpont Maaike, Pizzi Marco, Mazzoni Martina, Dei Tos Angelo Paolo, Amadori Alberto, Zanovello Paola, Van Vlierberghe Pieter, Yu Jiyang, Piovan ErichLEUKEMIA8.665
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemiaGarcía-Cañaveras Juan C., Lancho Olga, Ducker Gregory S., Ghergurovich Jonathan M., Xu Xincheng, da Silva-Diz Victoria, Minuzzo Sonia, Indraccolo Stefano, Kim Hahn, Herranz Daniel, Rabinowitz Joshua D.LEUKEMIA8.665
Identification of the true hyperdiploid multiple myeloma subset by combining conventional karyotyping and FISH analysisBarilà Gregorio, Bonaldi Laura, Grassi Angela, Martines Annalisa, Liço Albana, Macrì Nadia, Nalio Silvia, Pavan Laura, Berno Tamara, Branca Antonio, Calabretto Giulia, Carrino Marilena, Teramo Antonella, Manni Sabrina, Piazza Francesco, Semenzato Gianpietro, Zambello RenatoBLOOD CANCER JOURNAL8.023
Crosstalk between Hedgehog pathway and the glucocorticoid receptor pathway as a basis for combination therapy in T-cell acute lymphoblastic leukemiaBongiovanni Deborah, Tosello Valeria, Saccomani Valentina, Dalla Santa Silvia, Amadori Alberto, Zanovello Paola, Piovan ErichONCOGENE7.971
Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategyPasto Anna, Giordano Federica, Evangelopoulos Michael, Amadori Alberto, Tasciotti EnnioCLINICAL AND TRASLATIONAL MEDICINE7.919
Poly(L-glutamic acid)-co-poly(ethylene glycol) block copolymers for protein conjugationMaso Katia, Grigoletto Antonella, Raccagni Lucia, Bellini Marino, Marigo Ilaria, Ingangi Vincenzo, Suzuki Akira, Hirai Midori, Kamiya Masaki, Yoshioka Hiroki, Pasut GianfrancoJOURNAL OF CONTROLLED RELEASE7.727
The Bruton tyrosine kinase inhibitor ibrutinib improves anti-MAG antibody polyneuropathyCastellani Francesca, Visentin Andrea, Campagnolo Marta, Salvalaggio Alessandro, Cacciavillani Mario, Candiotto Cinzia, Bertorelle Roberta, Trentin Livio, Briani ChiaraNEUROLOGY-NEUROIMMUNOLOGY & AMP; NEUROINFLAMMATION7.724

Source: Biblioteca scientifica IOV

Top 15 pubblicazioni 2019 linea 1
TitoloAutoriRivistaIF grezzo
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancerCollaborators EMBRACE, Collaborators GC-HBOC Study, Collaborators GEMO Study, Investigators ABCTB, Investigators HEBON, Investigators BCFR, Ferreira Manuel A., Gamazon Eric R., Al-Ejeh Fares, Aittomäki Kristiina, Andrulis Irene L., Anton-Culver Hoda, Arason Adalgeir, Arndt Volker, Aronson Kristan J., Arun Banu K., Asseryanis Ella, Azzollini Jacopo, Balmaña Judith, Barnes Daniel R., Barrowdale Daniel, Beckmann Matthias W., Behrens Sabine, Benitez Javier, Bermisheva Marina, Bialkowska Katarzyna, Blomqvist Carl, Bogdanova Natalia V., Bojesen Stig E., Bolla Manjeet K., Borg Ake, Brauch Hiltrud, Brenner Hermann, Broeks Annegien, Burwinkel Barbara, Caldés Trinidad, Caligo Maria A., Campa Daniele, Campbell Ian, Canzian Federico, Carter Jonathan, Carter Brian D., Castelao Jose E., Chang-Claude Jenny, Chanock Stephen J., Christiansen Hans, Chung Wendy K., Claes Kathleen B.M., Clarke Christine L., Adlard Julian, Ahmed Munaza, Barwell Julian, Brady Angela, Montagna Marco, Radice Paolo, Viel Alessandra, Moserle Lidia, MULLIGAN Nature Communications11.878
Shared heritability and functional enrichment across six solid cancersJiang Xia, Finucane Hilary K., Schumacher Fredrick R., Schmit Stephanie L., Tyrer Jonathan P., Han Younghun, Michailidou Kyriaki, Lesseur Corina, Kuchenbaecker Karoline B., Dennis Joe, Conti David V., Casey Graham, Gaudet Mia M., Huyghe Jeroen R., Albanes Demetrius, Aldrich Melinda C., Andrew Angeline S., Andrulis Irene L., Anton-Culver Hoda, Antoniou Antonis C., Antonenkova Natalia N., Arnold Susanne M., Aronson Kristan J., Arun Banu K., Bandera Elisa V., Barkardottir Rosa B., Barnes Daniel R., Batra Jyotsna, Beckmann Matthias W., Benitez Javier, Benlloch Sara, Berchuck Andrew, Berndt Sonja I., Bickeböller Heike, Bien Stephanie A., Blomqvist Carl, Boccia Stefania, Bogdanova Natalia V., Bojesen Stig E., Bolla Manjeet K., Brauch Hiltrud, Brenner Hermann, Brenton James D., Brook Mark N., Brunet Joan, Brunnström Hans, Franceschi Silvia, Loupakis Fotios, Montagna Marco, Radice PaoloNature Communications11.878
Insulin/IGF1 signalling mediates the effects of ß2 -adrenergic agonist on muscle proteostasis and growthGonçalves Dawit A, Silveira Wilian A, Manfredi Leandro H, Graça Flávia A, Armani Andrea, Bertaggia Enrico, O Neill Brian T, Lautherbach Natalia, Machado Juliano, Nogara Leonardo, Pereira Marcelo G, Arcidiacono Diletta, realdon stefano, Kahn C Ronald, Sandri Marco, Kettelhut Isis C, Navegantes Luiz Carlos CJournal of Cachexia Sarcopenia and Muscle10.754
Avoiding unnecessary treatment of cervical intraepithelial neoplasia grade 2 (CIN2)Del Mistro AnnarosaCLINICAL INFECTIOUS DISEASES9.055
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and AggressivenessPatel V.L., Busch E.L., Friebel T.M., Cronin A., Leslie G., McGuffog L., Adlard J., Agata S., Agnarsson B.A., Ahmed M., Aittomäki K., Alducci Elisa, Andrulis I.L., Arason A., Arnold N., Artioli G., Arver B., Auber B., Azzollini J., Balmaña J., Barkardottir R.B., Barnes D.R., Barroso A., Barrowdale D., Belotti M., Benitez J., Bertelsen B., Blok M.J., Bodrogi I., Bonadona V., Bonanni B., Bondavalli D., Boonen S.E., Borde J., Borg A., Bradbury A.R., Brady A., Brewer C., Brunet J., Buecher B., Buys S.S., Cabezas-Camarero S., Caldés T., Caliebe A., Caligo M.A., Calvello M., Calvello M., Campbell I.G., Carnevali I., Carrasco E., Chan T.L., Chu A.T.W., Chung W.K., Claes K.B.M., Collaborators G.S., Collaborators E., Cook J., Cortesi L., Couch F.J., Daly M.B., Damante G., Darder E., Davidson R., de la Hoya M., Puppa L.D., Dennis J., Díez O., Ding Y.C., Ditsch N., Domchek S.M., Donaldson A., Dworniczak B., Easton D.F., Eccles D.M., Eeles R.A., Ehrencrona H., Ejlertsen B., Engel C., Evans D.G., Faivre L., Faust U., Feliubadaló L., Foretova L., Fostira F., Fountzilas G., Frost D., García-Barberán V., Garre P., Gauthier-Villars M., Géczi L., Gehrig A., Gerdes A.-M., Gesta P., Giannini G., Glendon G., Godwin A.K., Goldgar D.E., Greene M.H., Gutierrez-Barrera A.M., Hahnen E., Hamann U., Hauke J., Herold N., Hogervorst F.B.L., Honisch E., Hopper J.L., Hulick P.J., Investigators K., Investigators H., Izatt L., Jager A., James P., Janavicius R., Jensen U.B., Jensen T.D., Johannsson O.T., John E.M., Joseph V., Kang E., Kast K., Kiiski J.I., Kim S.-W., Kim Z., Ko K.-P., Konstantopoulou I., Kramer G., Krogh L., Kruse T.A., Kwong A., Larsen M., Lasset C., Lautrup C., Lazaro C., Lee J., Lee J.W., Lee M.H., Lemke J., Lesueur F., Liljegren A., Lindblom A., Llovet P., Lopez-Fernández A., Lopez-Perolio I., Lorca V., Loud J.T., Ma E.S.K., Mai P.L., Manoukian S., Mari V., Martin L., Matricardi Laura, Mebirouk N., Medici V., Meijers-Heijboer H.E.J., Meindl A., Mensenkamp A.R., Miller C., Gomes D.M., Montagna Marco, Mooij T.M., Moserle Lidia, Mouret-Fourme E., Mulligan A.M., Nathanson K.L., Navratilova M., Nevanlinna H., Niederacher D., Nielsen F.C.C., Nikitina-Zake L., Offit K., Olah E., Olopade O.I., Ong K.-R., Osorio A., Ott C.-E., Palli D., Park S.K., Parsons M.T., Pedersen I.S., Peissel B., Peixoto A., Pérez-Segura P., Peterlongo P., Petersen A.H., Porteous M.E., Pujana M.A., Radice P., Ramser J., Rantala J., Rashid M.U., Rhiem K., Rizzolo P., Robson M.E., Rookus M.A., Rossing C.M., Ruddy K.J., Santos C., Saule C., Scarpitta R., Schmutzler R.K., Schuster H., Senter L., Seynaeve C.M., Shah P.D., Sharma P., Shin V.Y., Silvestri V., Simard J., Singer C.F., Skytte A.-B., Snape K., Solano A.R., Soucy P., Southey M.C., Spurdle A.B., Steele L., Steinemann D., Stoppa-Lyonnet D., Stradella A., Sunde L., Sutter C., Tan Y.Y., Teixeira M.R., Teo S.H., Thomassen M., Tibiletti M.G., Tischkowitz M., Tognazzo Silvia, Toland A.E., Tommasi S., Torres D., Toss A., Trainer A.H., Tung N., van Asperen C.J., van der Baan F.H., van der Kolk L.E., van der Luijt R.B., van Hest L.P., Varesco L., Varon-Mateeva R., Viel A., Vierstrate J., Villa R., von Wachenfeldt A., Wagner P., Wang-Gohrke S., Wappenschmidt B., Weitzel J.N., Wieme G., Yadav S., Yannoukakos D., Yoon S.-Y., Zanzottera C., Zanzottera C., Zorn K.K., D’Amico A.V., Freedman M.L., Pomerantz M.M., Chenevix-Trench G., Antoniou A.C., Neuhausen S.L., Ottini L., Nielsen H.R., Rebbeck T.R.CANCER RESEARCH8.378
Dissecting molecular mechanisms of resistance to Notch1-targeted therapy in T-cell acute lymphoblastic leukemia xenograftsAgnusdei Valentina, Minuzzo Sonia, Pinazza Marica, Gasparini Alessandra, Pezzè Laura, Amaro Adriana Agnese, Pasqualini Lorenza, Del Bianco Paola, Tognon Martina, Frasson Chiara, Palumbo Pietro, Ciribilli Yari, Pfeffer Ulrich, Carella Massimo, Amadori Alberto, Indraccolo StefanoHaematologica-The Hematology Journal7.57
Immune activation, immune senescence and levels of Epstein Barr Virus in kidney transplant patientsPetrara Maria Raffaella, Serraino Diego, Di Bella Caterina, Neri Flavia, Del Bianco Paola, Brutti Martina, Carmona Francesco, Ballin Giovanni, Zanini Stefano, Rigotti Paolo, Furian Lucrezia, De Rossi AnitaCANCER LETTERS6.508
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancerMazzoldi Elena Laura, Pavan Simona, Pilotto Giorgia, Leone Kevin, Pagotto Anna, Frezzini Simona, NICOLETTO MARIA ORNELLA, Amadori Alberto, Pasto AnnaCell Death & Disease5.959
Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenograftsRicci Francesca, Brunelli Laura, Affatato Roberta, Chilà Rosaria, Verza Martina, Indraccolo Stefano, Falcetta Francesca, Fratelli Maddalena, Fruscio Robert, Pastorelli Roberta, Damia GiovannaTherapeutic Advances in Medical Oncology5.67
Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF TherapyCurtarello Matteo, Tognon Martina, Venturoli Carolina, silic-benussi micol, Grassi Angela, Verza Martina, Minuzzo Sonia, Pinazza Marica, Brillo Valentina, Tosi Giovanni, Ferrazza Ruggero, Guella Graziano, Iorio Egidio, Godfroid Adrien, Sounni Nor Eddine, Amadori Alberto, Indraccolo StefanoCells5.656
The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid OrganelleJoukov Vladimir, De Nicolo ArcangelaCells5.656
Immune senescence and immune activation in elderly colorectal cancer patientsGiunco Silvia, Petrara Maria Raffaella, bergamo francesca, Del Bianco Paola, Zanchetta Marisa, Carmona Francesco, zagonel vittorina, De Rossi Anita, Lonardi SaraAging-US5.515
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriersQian F, Rookus MA, …, Montagna Marco, Tognazzo Silvia, …, on behalf of CIMBABRITISH JOURNAL OF CANCER5.416
Metabolic rewiring and redox alterations in malignant pleural mesotheliomaUrso Loredana, Cavallari Ilaria, Sharova Evgeniya, Ciccarese Francesco, Pasello Giulia, Ciminale VincenzoBRITISH JOURNAL OF CANCER5.416
Oncogenic pathways and the electron transport chain: a dangeROS liaisonRaimondi Vittoria, Ciccarese Francesco, Ciminale VincenzoBRITISH JOURNAL OF CANCER5.416

Source: Biblioteca scientifica IOV

Top 15 pubblicazioni 2021 linea 1
TitoloAutoriTestataIF grezzo
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriersCollaborators GEMO Study, Coignard Juliette, Lush Michael, Beesley Jonathan, O’Mara Tracy A, Dennis Joe, Tyrer Jonathan P, Barnes Daniel R, McGuffog Lesley, Leslie Goska, Bolla Manjeet K, Adank Muriel A, Agata Simona, Ahearn Thomas, Aittomäki Kristiina, Andrulis Irene L, Anton-Culver Hoda, Arndt Volker, Arnold Norbert, Aronson Kristan J, Arun Banu K, Augustinsson Annelie, Azzollini Jacopo, Barrowdale Daniel, Baynes Caroline, Becher Heiko, Bermisheva Marina, Bernstein Leslie, Bia¿kowska Katarzyna, Blomqvist Carl, Bojesen Stig E, Bonanni Bernardo, Borg Ake, Brauch Hiltrud, Brenner Hermann, Burwinkel Barbara, Buys Saundra S, Caldés Trinidad, Caligo Maria A, Campa Daniele, Carter Brian D, Castelao Jose E, Chang-Claude Jenny, Chanock Stephen J, Chung Wendy K, Claes Kathleen B M, Clarke Christine L, Collée J Margriet, Manoukian Siranoush, Montagna Marco, Radice PaoloNature Communications14.919
Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores.Collaborators GEMO Study, Barnes Daniel R, Silvestri Valentina, Leslie Goska, McGuffog Lesley, Dennis Joe, Yang Xin, Adlard Julian, Agnarsson Bjarni A, Ahmed Munaza, Aittomäki Kristiina, Andrulis Irene L, Arason Adalgeir, Arnold Norbert, Auber Bernd, Azzollini Jacopo, Balmaña Judith, Barkardottir Rosa B, Barrowdale Daniel, Barwell Julian, Belotti Muriel, Benitez Javier, Berthet Pascaline, Boonen Susanne E, Borg Åke, Bozsik Aniko, Brady Angela, Brennan Paul, Brewer Carole, Brunet Joan, Bucalo Agostino, Buys Saundra S, Caldés Trinidad, Caligo Maria A, Campbell Ian, Cassingham Hayley, Lotte Christensen Lise, Cini Giulia, Claes Kathleen B M, Cook Jackie, Coppa Anna, Cortesi Laura, Damante Giuseppe, Darder Esther, Manoukian Siranoush, Matricardi Laura, Montagna Marco, Peissel Bernard, Radice Paolo, Tommasi Stefania, Viel AlessandraJOURNAL OF THE NATIONAL CANCER INSTITUTE13.506
Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortiaB Dalmasso, L Pastorino, V Nathan, N N Shah, J M Palmer, M Howlie, P A Johansson, N D Freedman, B D Carter, L Beane-Freeman, B Hicks, A Molven, H Helgadottir, A Sankar, H Tsao, A J Stratigos, P Helsing, R Van Doorn, N A Gruis, M Visser, K A W Wadt, G Mann, E A Holland, E Nagore, M Potrony, S Puig, Menin Chiara, K Peris, M C Fargnoli, D Calista, N Soufir, M Harland, T Bishop, P A Kanetsky, D E Elder, V Andreotti, I Vanni, W Bruno, V Höiom, M A Tucker, X R Yang, P A Andresen, D J Adams, M T Landi, N K Hayward, A M Goldstein, P Ghiorzo, GenoMEL, MelaNostrum consortiaGENETICS IN MEDICINE8.822
The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variantGEMO Study Collaborators Gruppo, EMBRACE Collaborators Gruppo, OCGN Investigators Gruppo, HEBON Investigators Gruppo, KConFab Investigators Gruppo, Lakeman Inge M.M., van den Broek Alexandra J., Vos Juliën A.M., Barnes Daniel R., Adlard Julian, Andrulis Irene L., Arason Adalgeir, Arnold Norbert, Arun Banu K., Balmaña Judith, Barrowdale Daniel, Benitez Javier, Borg Ake, Caldés Trinidad, Caligo Maria A., Chung Wendy K., Claes Kathleen B.M., Barouk-Simonet Emmanuelle, Belotti Muriel, Berthet Pascaline, Bignon Yves Jean, Bonadona Valérie, Bressac-de Paillerets Brigitte, Buecher Bruno, Caputo Sandrine, Caron Olivier, Castera Laurent, Caux-Moncoutier Virginie, Colas Chrystelle, Collonge-Rame Marie Agnès, Coupier Isabelle, de Pauw Antoine, Delnatte Capucine, Elan Camille, Faivre Laurence, Ferrer Sandra Fert, Gauthier-Villars Marion, Gesta Paul, Giraud Sophie, Golmard Lisa, Houdayer Claude, Lasset Christine, Laurent Maïté, Leroux Dominique, Longy Michel, Mari Véronique, Goldgar David E., Manoukian Siranoush, Montagna Marco, Goldgar David E.GENETICS IN MEDICINE8.822
BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancerRaimundo Liliana, Paterna Angela, Calheiros Juliana, Ribeiro Joana, Cardoso David S P, Piga Ilaria, Neto Susana Junqueira, Hegan Denise, Glazer Peter M, INDRACCOLO STEFANO, Mulhovo Silva, Costa José Luís, Ferreira Maria-José U, Saraiva LucíliaBRITISH JOURNAL OF PHARMACOLOGY8.74
Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced ColitisTolomeo Anna Maria, Castagliuolo Ignazio, Piccoli Martina, Grassi Michele, Magarotto Fabio, De Lazzari Giada, Malvicini Ricardo, Caicci Federico, Franzin Chiara, Scarpa Melania, Macchi Veronica, De Caro Raffaele, Angriman Imerio, Viola Antonella, Porzionato Andrea, Pozzobon Michela, Muraca MaurizioFrontiers in Immunology7.561
Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 InfectionSandgaard Katrine Schou, Margetts Ben, Attenborough Teresa, Gkouleli Triantafylia, Adams Stuart, Holm Mette, Gibb Diana, Gibbons Deena, Giaquinto Carlo, DE ROSSI ANITA, Bamford Alasdair, Palma Paolo, Chain Benny, Gkazi Athina S., Klein NigelFrontiers in Immunology7.561
T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individualsEPIICAL Consortium Gruppo, Rinaldi Stefano, de Armas Lesley, Dominguez-Rodríguez Sara, Pallikkuth Suresh, Dinh Vinh, Pan Li, G¿rtner Kathleen, Pahwa Rajendra, Cotugno Nicola, Rojo Pablo, Nastouli Eleni, Klein Nigel, Foster Caroline, DE ROSSI ANITA, Giaquinto Carlo, Rossi Paolo, Palma Paolo, Pahwa SavitaPLoS Pathogens6.823
Analysis of Italian BRCA1/2 Pathogenic Variants Identifies a Private Spectrum in the Population from the Bergamo Province in Northern ItalyFiglioli Gisella, De Nicolo Arcangela, Catucci Irene, Manoukian Siranoush, Peissel Bernard, Azzollini Jacopo, Beltrami Benedetta, Bonanni Bernardo, Calvello Mariarosaria, Bondavalli Davide, Pasini Barbara, Vignolo Lutati Francesca, Ogliara Paola, Zuradelli Monica, Pensotti Valeria, De Vecchi Giovanna, Volorio Sara, Verderio Paolo, Pizzamiglio Sara, Matullo Giuseppe, Aneli Serena, Birolo Giovanni, Zanardi Federica, Tondini Carlo, Zambelli Alberto, Livraghi Luca, Franchi Michela, Radice Paolo, Peterlongo PaoloCancers6.639
Comprehensive Profiling of Hypoxia-Related miRNAs Identifies miR-23a-3p Overexpression as a Marker of Platinum Resistance and Poor Prognosis in High-Grade Serous Ovarian CancerTodeschini Paola, Salviato Elisa, Romani Chiara, Raimondi Vittoria, Ciccarese Francesco, Ferrari Federico, Tognon Germana, Marchini Sergio, D’Incalci Maurizio, Zanotti Laura, Ravaggi Antonella, Odicino Franco, Sartori Enrico, D’Agostino Donna Mia, Samaja Michele, Romualdi Chiara, Bignotti ElianaCancers6.639
Novel perspectives in pseudomyxoma peritonei treatmentSommariva Antonio, Tonello Marco, Rigotto Giulia, Lazzari Nayana, pilati pierluigi, Calabro’ Maria LuisaCancers6.639
The miR-200 family of microRNAs: Fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkersCAVALLARI ILARIA, Ciccarese Francesco, Sharova Evgeniya, URSO LOREDANA, Raimondi Vittoria, Silic-Benussi Micol, D’Agostino Donna Mia, Ciminale VincenzoCancers6.639
Genetic perturbation of pyruvate dehydrogenase kinase 1 modulates growth, angiogenesis and metabolic pathways in ovarian cancer xenograftsVenturoli Carolina, Piga Ilaria, Curtarello Matteo, Verza Martina, Esposito Giovanni, Venuto Santina, Navaglia Filippo, Grassi Angela, INDRACCOLO STEFANOCells6.6
Clinical relevance of partial HPV16/18 genotyping in stratifying HPV-positive women attending routine cervical cancer screening: a population-based cohort studyGori Silvia, Battagello J., Gustinucci D., Campari C., Frayle Helena, Zorzi M., Passamonti B., sartori giuliana, Bulletti S., Fodero C., Cesarini E., faggiano roberto cosimo, Del Mistro AnnarosaBJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY6.531
Adrenomedullin Expression Characterizes Leukemia Stem Cells and Associates With an Inflammatory Signature in Acute Myeloid LeukemiaSimonetti Giorgia, Angeli Davide, Petracci Elisabetta, Fonzi Eugenio, Vedovato Susanna, Sperotto Alessandra, Padella Antonella, Ghetti Martina, Ferrari Anna, Robustelli Valentina, Di Liddo Rosa, Conconi Maria Teresa, Papayannidis Cristina, Cerchione Claudio, Rondoni Michela, Astolfi Annalisa, Ottaviani Emanuela, Martinelli Giovanni, Gottardi MicheleFrontiers in Oncology6.244

Source: Biblioteca scientifica IOV

Last modified: 18/02/2022 09:25

Sitemap

  • Ultima modifica: 18/02/2022
Facebook Twitter Instagram Youtube Heart
IOV - Istituto Oncologico Veneto - IRCCS | Via Gattamelata, 64 - 35128 Padova (PD) Italy | C.F./P.IVA 04074560287

Last website update

Scroll to Top