LINE 2 – immunology of tumors

LINE 2 – immunology of tumors


Prof. Antonio Rosato


This research line aims to analyze the interactions between immunity and cancer, and to identify, propose, and implement therapeutic solutions based on the stimulation of the effector components of the immune system. At IOV, these aspects will be studied through:

  • the evaluation in experimental models of the efficacy of new vaccine formulations, of adoptive immunotherapy approaches, and of pharmacological interventions aimed at restoring the full efficiency of the immune system;
  • the analysis and identification of new immune and prognostic and / or predictive biomarkers in the context of the current clinical activity and the experiments already underway.


Immunotherapy of tumors is experiencing an important phase of cultural renaissance, particularly thanks to the recent introduction, into the armament of cancer therapies, of immune checkpoint inhibitors (ICI) and monoclonal antibodies (mAb) able to prevent the feedback inhibition of activated T cell, and to stimulate protective and therapeutic T cell responses directed against tumor neoantigens deriving from mutations of normal neoplastic cell proteins, which behave as highly tumor-specific antigens. These observations present potentially important breakthroughs, as they allow us to envision, on the one hand, possible personalized immunotherapeutic interventions, and, on the other, to conceive combinatorial therapies of ICI and vaccines and / or adoptive therapies with T cells able to favor the expansion and functionality of highly effective effector populations.


The introduction of ICIs in current oncology practice is dramatically changing the expectations of clinical outcomes for some tumor types; however, it also imposes, in an equally dramatic way, the identification of predictive biomarkers of response capable of guiding patient selection, in order to rationalize and personalize therapies in view of both toxicity profiles and cost effectiveness. On the other hand, vaccine and cellular immunotherapeutic strategies are virtually unrecognized in our country on the basis of cultural and research deficiencies, and of technological, regulatory, and economic difficulties to implement these approaches, in particular, the engineering of T cells. Moreover, a strategic plan to develop adequate facilities for the manufacture of cellular drugs for therapeutic use is lacking.

Global goals

  • to obtain immunogenetic profiles of neoplasms of immunological relevance;
  • to obtain cellular immunoprofiles at the peripheral level and in the tumor-stroma (immunoscore);
  • to develop preclinical models for the experimentation of innovative immunotherapies.

Expected results

Expected results during the three-year period include: a) the implementation of an integrated immunoprofiling platform based on NGS, cytometry, and digital pathology able to identify and validate new prognostic or predictive biomarkers; b) the strengthening of preclinical adoptive immunotherapy studies to be effectively transferred into phase 1 clinical studies.

Top 15 pubblicazioni Linea 2 anno 2020
TitoloAutori/AutriciRivista IF grezzo
Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III MelanomaReinhard Dummer, Axel Hauschild, Mario Santinami, Victoria Atkinson, Mario Mandalà , John M Kirkwood , chiarion sileni vanna, James Larkin, Marta Nyakas, Caroline Dutriaux, Andrew Haydon , Caroline Robert , Laurent Mortier, Jacob Schachter, Thierry Lesimple, Ruth Plummer , Kohinoor Dasgupta , Eduard Gasal , Monique Tan, Georgina V Long, Dirk SchadendorfNEW ENGLAND JOURNAL OF MEDICINE74.699
Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical propertiesPanciera Tito, Citron Anna, Di Biagio Daniele, Battilana Giusy, Gandin Alessandro, Giulitti Stefano, Forcato Mattia, Bicciato Silvio, Panzetta Valeria, Fusco Sabato, Azzolin Luca, Totaro Antonio, Dei Tos Angelo Paolo, Fassan Matteo, Vindigni Vincenzo, Bassetto Franco, Rosato Antonio, Brusatin Giovanna, Cordenonsi Michelangelo, Piccolo StefanoNATURE MATERIALS38.663
Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial >Reinhard Dummer, Jan C Brase, James Garrett, Catarina D Campbell, Eduard Gasal, Matthew Squires, Daniel Gusenleitner , Mario Santinami , Victoria Atkinson , Mario Mandalà, chiarion sileni vanna, Keith Flaherty , James Larkin, Caroline Robert , Richard Kefford, John M Kirkwood , Axel Hauschild , Dirk Schadendorf , Georgina V LongLANCET ONCOLOGY33.752
Adjuvant nivolumab versus ipilimumab in resected stage IIIB-C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trialAscierto Paolo A., Del Vecchio Michele, Mandalá Mario, Gogas Helen, Arance Ana M., Dalle Stephane, Cowey C. Lance, Schenker Michael, Grob Jean Jacques, chiarion sileni vanna, Márquez-Rodas Iván, Butler Marcus O., Maio Michele, Middleton Mark R., de la Cruz-Merino Luis, Arenberger Petr, Atkinson Victoria, Hill Andrew, Fecher Leslie A., Millward Michael, Khushalani Nikhil I., Queirolo Paola, Lobo Maurice, de Pril Veerle, Loffredo John, Larkin James, Weber JeffreyLANCET ONCOLOGY33.752
Five-year outcomes with nivolumab in patients with wild-type BRAF advanced melanomaRobert Caroline, Long Georgina V., Brady Benjamin, Dutriaux Caroline, Di Giacomo Anna Maria, Mortier Laurent, Rutkowski Piotr, Hassel Jessica C., McNeil Catriona M., Kalinka Ewa Anna, Lebbé Céleste, Charles Julie, Hernberg Micaela M., Savage Kerry J., chiarion sileni vanna, Mihalcioiu Catalin, Mauch Cornelia, Arance Ana, Cognetti Francesco, Ny Lars, Schmidt Henrik, Schadendorf Dirk, Gogas Helen, Zoco Jesús, Re Sandra, Ascierto Paolo A., Atkinson VictoriaJOURNAL OF CLINICAL ONCOLOGY32.956
Pregnancy After Breast Cancer in Patients With Germline BRCA MutationsLambertini Matteo, Ameye Lieveke, Hamy Anne Sophie, Zingarello Anna, Poorvu Philip D., Carrasco Estela, Grinshpun Albert, Han Sileny, Rousset-Jablonski Christine, Ferrari Alberta, Paluch-Shimon Shani, Cortesi Laura, Senechal Claire, Miolo Gianmaria, Pogoda Katarzyna, Pérez-Fidalgo Jose Alejandro, De Marchis Laura, Ponzone Riccardo, Livraghi Luca, Estevez-Diz Maria Del Pilar, Villarreal-Garza Cynthia, Dieci Maria Vittoria, Clatot Florian, Berlière Martine, Graffeo Rossella, Teixeira Luis, Córdoba Octavi, Sonnenblick Amir, Luna Pais Helena, Ignatiadis Michail, Paesmans Marianne, Partridge Ann H., Caron Olivier, Saule Claire, Del Mastro Lucia, Peccatori Fedro A., Azim Hatem A.JOURNAL OF CLINICAL ONCOLOGY32.956
Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretomeCapaci Valeria, Bascetta Lorenzo, Fantuz Marco, Beznoussenko Galina V., Sommaggio Roberta, Cancila Valeria, Bisso Andrea, Campaner Elena, Mironov Alexander A., Wi¿niewski Jacek R., Ulloa Severino Luisa, Scaini Denis, Bossi Fleur, Lees Jodi, Alon Noa, Brunga Ledia, Malkin David, Piazza Silvano, Collavin Licio, Rosato Antonio, Bicciato Silvio, Tripodo Claudio, Mantovani Fiamma, Del Sal GianninoNATURE COMMUNICATIONS12.121
Overall survival at 5 years of follow-up in a phase III trial comparing ipilimumab 10 mg/kg with 3 mg/kg in patients with advanced melanomaAscierto Paolo Antonio, Del Vecchio Michelle, Mackiewicz Andrzej, Robert Caroline, chiarion sileni vanna, Arance Ana, Lebbé Céleste, Svane Inge Marie, Mcneil Catriona, Rutkowski Piotr, Loquai Carmen, Mortier Laurent, Hamid Omid, Bastholt Lars, Dreno Brigitte, Schadendorf Dirk, Garbe Claus, Nyakas Marta, Grob Jean Jacques, Thomas Luc, Liszkay Gabriella, Smylie Michael, Hoeller Christoph, Ferraresi Virginia, Grange Florent, Gutzmer Ralf, Pikiel Joanna, Hosein Fareeda, Simsek Burcin, Maio MicheleJOURNAL OF IMMUNOTHERAPY OF CANCER10.252
Biomarkers for HER2-positive metastatic breast cancer: Beyond hormone receptorsDieci Maria Vittoria, Miglietta Federica, Griguolo Gaia, Guarneri ValentinaCANCER TREATMENT REVIEWS8.885
Integration of tumour infiltrating lymphocytes, programmed cell-death ligand-1, CD8 and FOXP3 in prognostic models for triple-negative breast cancer: Analysis of 244 stage I-III patients treated with standard therapyDieci Maria Vittoria, Tsvetkova Vassilena, Griguolo Gaia, Miglietta Federica, Tasca Giulia, Giorgi Carlo Alberto, Cumerlato Enrico, Massa Davide, Lo Mele Marcello, Orvieto Enrico, Guarneri Valentina, Conte PierfrancoEUROPEAN JOURNAL OF CANCER7.275
Targeting of immunosuppressive myeloid cells from glioblastoma patients by modulation of size and surface charge of lipid nanocapsulesPinton Laura, Sara Magri, Elena Masetto, Marina Vettore, Ilaria Schibuola, Ingangi Vincenzo, Marigo Ilaria, Kevin Matha, Jean-Pierre Benoit, Alessandro Della Puppa, Vincenzo Bronte, Giovanna Lollo, Mandruzzato SusannaJOURNAL OF NANOBIOTECHNOLOGY6.518
Reactive Oxygen Species and Antitumor Immunity-From Surveillance to EvasionKOTSAFTI ANDROMACHI, Scarpa Marco, Castagliuolo Ignazio, Scarpa MelaniaCANCERS6.126
The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practiceInternational Immuno-Oncology Biomarker Working Group Gruppo, Gonzalez-Ericsson Paula I, Stovgaard Elisabeth S, Sua Luz F, Reisenbichler Emily, Kos Zuzana, Carter Jodi M, Michiels Stefan, Le Quesne John, Nielsen Torsten O, Laenkholm Anne-Vibeke, Fox Stephen B, Adam Julien, Bartlett John Ms, Rimm David L, Quinn Cecily, Peeters Dieter, Dieci Maria Vittoria, Vincent-Salomon Anne, Cree Ian, Hida Akira I, Balko Justin M, Haynes Harry R, Frahm Isabel, Acosta-Haab Gabriela, Balancin Marcelo, Bellolio Enrique, Yang Wentao, Kirtani Pawan, Sugie Tomoharu, Ehinger Anna, Castaneda Carlos A, Kok Marleen, McArthur Heather, Siziopikou Kalliopi, Badve Sunil, Fineberg Susan, Gown Allen, Viale Giuseppe, Schnitt Stuart J, Pruneri Giancarlo, Penault-Llorca Frederique, Hewitt Stephen, Thompson E Aubrey, Allison Kimberly H, Symmans William F, Bellizzi Andrew M, Brogi Edi, Moore David A, Larsimont Denis, Dillon Deborah A.JOURNAL OF PATHOLOGY6.021
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancerKos Zuzana, Roblin Elvire, Kim Rim S, Michiels Stefan, Gallas Brandon D, Chen Weijie, van de Vijver Koen K, Goel Shom, Adams Sylvia, Demaria Sandra, Viale Giuseppe, Nielsen Torsten O, Badve Sunil S, Symmans W Fraser, Sotiriou Christos, Rimm David L, Hewitt Stephen, Denkert Carsten, Loibl Sibylle, Luen Stephen J, Bartlett John M S, Savas Peter, Pruneri Giancarlo, Dillon Deborah A, Cheang Maggie Chon U, Tutt Andrew, Hall Jacqueline A, Kok Marleen, Horlings Hugo M, Madabhushi Anant, van der Laak Jeroen, Ciompi Francesco, Laenkholm Anne-Vibeke, Bellolio Enrique, Gruosso Tina, Fox Stephen B, Araya Juan Carlos, Floris Giuseppe, Hude¿ek Jan, Voorwerk Leonie, Beck Andrew H, Kerner Jen, Larsimont Denis, Declercq Sabine, Van den Eynden Gert, Pusztai Lajos, Ehinger Anna, Yang Wentao, Curigliano Giuseppe, Dieci Maria Vittoria, International Immuno-Oncology Biomarker Working Group GruppoNPJ BREAST CANCER6
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cellsSommaggio Roberta, Cappuzzello Elisa, Dalla Pietà Anna, Tosi Anna, Palmerini Pierangela, Carpanese Debora, Nicolè Lorenzo, Rosato AntonioONCOIMMUNOLOGY5.869

Source: Biblioteca scientifica IOV

Top 15 pubblicazioni 2019 linea 2
TitoloAutori Rivista IF grezzo
Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast CancersLoi S, Drubay D, Adams S, Pruneri G, Francis PA, Lacroix-Triki M, Joensuu H, Dieci Maria Vittoria, Badve S, Demaria S, Gray R, Munzone E, Lemonnier J, Sotirou C, Piccart MJ, Kellokumpu-Lehtinen PL, Vingiani A, Gray K, Andre F, Denkert C, Salgado R, Michiels SJOURNAL OF CLINICAL ONCOLOGY28.349
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockadeJacquelot Nicolas, Yamazaki Takahiro, Roberti Maria P, Duong Connie P M, Andrews Miles C, Verlingue Loic, Ferrere Gladys, Becharef Sonia, Vétizou Marie, Daillère Romain, Messaoudene Meriem, Enot David P, Stoll Gautier, Ugel Stefano, Marigo Ilaria, Foong Ngiow Shin, Marabelle Aurélien, Prevost-Blondel Armelle, Gaudreau Pierre-Olivier, Gopalakrishnan Vancheswaran, Eggermont Alexander M, Opolon Paule, Klein Christophe, Madonna Gabriele, Ascierto Paolo A, Sucker Antje, Schadendorf Dirk, Smyth Mark J, Soria Jean-Charles, Kroemer Guido, Bronte Vincenzo, Wargo Jennifer, Zitvogel LaurenceCELL RESEARCH17.848
Association of tumor-infiltrating lymphocytes with distant disease-free survival in the ShortHER randomized adjuvant trial for patients with early HER2+ breast cancerDieci Maria Vittoria, Conte Pierfranco, Bisagni G., Brandes A.A., Frassoldati A., Cavanna L., Musolino A., Giotta F., Rimanti A., Garrone O., Bertone E., Cagossi K., Sarti S., Ferro A., Piacentini F., Maiorana A., Maiorana A., Orvieto E., Sanders M., Miglietta F., Balduzzi S., D’Amico R., Guarneri ValentinaANNALS OF ONCOLOGY14.196
Prognostic value of tumor-infiltrating lymphocytes in patients with early-stage triple-negative breast cancers (TNBC) who did not receive adjuvant chemotherapyPark J H, Jonas S F, Bataillon G, Criscitiello C, Salgado R, Loi S, Viale G, Lee H J, Dieci Maria Vittoria, Kim S-B, Vincent-Salomon A, Curigliano G, André F, Michiels SANNALS OF ONCOLOGY14.196
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3Trovato Rosalinda, Fiore Alessandra, Sartori Sara, Canè Stefania, Giugno Rosalba, Cascione Luciano, Paiella Salvatore, Salvia Roberto, De Sanctis Francesco, Poffe Ornella, Anselmi Cristina, Hofer Francesca, Sartoris Silvia, Piro Geny, Carbone Carmine, Carbone Carmine, Corbo Vincenzo, Lawlor Rita, Solito Samantha, Pinton Laura, Mandruzzato Susanna, Bassi Claudio, Scarpa Aldo, Bronte Vincenzo, Ugel StefanoJournal for ImmunoTherapy of Cancer8.728
Interaction of host immunity with HER2-targeted treatment and tumor heterogeneity in HER2-positive breast cancerGriguolo Gaia, Pascual Tomás, Dieci Maria Vittoria, Guarneri Valentina, Prat AleixJournal for ImmunoTherapy of Cancer8.728
The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesionPinton Laura, Masetto Elena, Vettore Marina, Solito Samantha, Magri Sara, D’Andolfi Marta, Del Bianco Paola, Lollo Giovanna, Benoit Jean-Pierre, Okada Hideho, Diaz Aaron, Della Puppa Alessandro, Mandruzzato SusannaJournal for ImmunoTherapy of Cancer8.728
Diabetes-Associated Myelopoiesis Drives Stem Cell Mobilopathy Through an OSM-p66Shc Signaling PathwayAlbiero M, Ciciliot S, Tedesco S, Menegazzo L, D’Anna M, Scattolini V, Cappellari R, Zuccolotto G, Rosato Antonio, Cignarella A, Giorgio M, Avogaro A, Fadini GPDIABETES7.199
Inclusion of Platinum Agents in Neoadjuvant Chemotherapy Regimens for Triple-Negative Breast Cancer PatientsDieci Maria Vittoria, Del Mastro Lucia, Cinquini Michela, Montemurro Filippo, Biganzoli Laura, Cortesi Laura, Zambelli Alberto, Criscitiello Carmen, Levaggi Alessia, Conte Benedetta, Calabrese Massimo, Fiorentino Alba, Marchiò Caterina, Tinterri Corrado, Fittipaldo Veronica Andrea, Pappagallo Giovanni, Gori StefaniaCancers6.162
Programmed Cell Death Ligand 1 in Breast Cancer: Technical Aspects, Prognostic Implications, and Predictive ValueMiglietta Federica, Griguolo Gaia, Guarneri Valentina, Dieci Maria VittoriaONCOLOGIST5.252
177Lu-Bombesin-PLGA (paclitaxel): A targeted controlled-release nanomedicine for bimodal therapy of breast cancerGibbens-Bandala Brenda, Morales-Avila Enrique, Ferro-Flores Guillermina, Santos-Cuevas Clara, Melendez Alafort Laura, Trujillo-Nolasco Maydelid, Ocampo-García BlancaMaterials Science & Engineering C-Materials for Biological Applications4.959
The Endless Saga of Monocyte DiversityCanè Stefania, Ugel Stefano, Trovato Rosalinda, Marigo Ilaria, De Sanctis Francesco, Sartoris Silvia, Bronte VincenzoFrontiers in Immunology4.716
A non-covalent antibody complex for the delivery of anti-cancer drugsMaso Katia, montagner isabella monia, Grigoletto Antonella, Schiavon Oddone, Rosato Antonio, Pasut GianfrancoEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS4.708
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysisDi Paolo Veronica, Fulci Chiara, Rotili Dante, Sciarretta Francesca, Lucidi Alessia, Morozzo Della Rocca Blasco, De Luca Anastasia, Rosato Antonio, Quintieri Luigi, Caccuri Anna MariaJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY4.027
Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activityMinopoli Michele, Polo Andrea, Ragone Concetta, Ingangi Vincenzo, Ciliberto Gennaro, Pessi Antonello, Sarno Sabrina, Budillon Alfredo, Costantini Susan, Carriero Maria VincenzaScientific Reports4.011

Source: Biblioteca scientifica IOV

Top 15 pubblicazioni 2021 linea 2
TitoloAutoriTestataIF grezzo
Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signaturesFranciosa Giulia, Smits Jos G.A., Minuzzo Sonia, Martinez-Val Ana, INDRACCOLO STEFANO, Olsen Jesper V.Nature Communications14.919
Innovative therapeutic strategy for B-cell malignancies that combines obinutuzumab and cytokine-induced killer cellsDalla Pietà Anna, Cappuzzello Elisa, Palmerini Pierangela, Ventura Annavera, Visentin Andrea, Astori Giuseppe, Chieregato Katia, Mozzo Valentina, Perbellini Omar, Tisi Maria Chiara, Trentin Livio, Visco Carlo, Ruggeri Marco, sommaggio roberta, ROSATO ANTONIOJournal for ImmunoTherapy of Cancer13.751
Neoadjuvant Chemotherapy and Immunotherapy in Luminal B-like Breast Cancer: Results of the Phase II GIADA TrialDIECI MARIA VITTORIA, Guarneri Valentina, Tosi Anna, Bisagni Giancarlo, Musolino Antonino, Spazzapan Simon, Moretti Gabriella, VERNACI GRAZIA MARIA, Griguolo Gaia, GIARRATANO TOMMASO, Urso Loredana, SCHIAVI FRANCESCA, Pinato Claudia, Magni Giovanna, Lo Mele Marcello, De Salvo Gian Luca, ROSATO ANTONIO, Conte PierfrancoCLINICAL CANCER RESEARCH12.531
Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemiaXiong Huizhong, Mancini Maicol, Gobert Michael, Shen Shiqian, Furtado Glaucia C., Lira Sergio A., Parkhurst Christopher N., Garambois Veronique, Brengues Muriel, Tadokoro Carlos E., Trimarchi Thomas, Gómez-López Gonzalo, Singh Amartya, Khiabanian Hossein, Minuzzo Sonia, INDRACCOLO STEFANO, Lobry Camille, Aifantis Iannis, Herranz Daniel, Lafaille Juan J., Maraver AntonioTheranostics11.556
Hyaluronan is a natural and effective immunological adjuvant for protein-based vaccinesDalla Pietà Anna, Carpanese Debora, Grigoletto Antonella, Tosi Anna, Dalla Santa Silvia, Pedersen Gabriel Kristian, Christensen Dennis, Melendez Alafort Laura, Barbieri Vito, De Benedictis Paola, Pasut Gianfranco, Montagner Isabella Monia, ROSATO ANTONIOCellular & Molecular Immunology11.53
The immune cell landscape of metastatic uveal melanoma correlates with overall survivalTosi Anna, Cappellesso Rocco, Dei Tos Angelo Paolo, Rossi Valentina, Aliberti Camillo, PIGOZZO JACOPO, Fabozzi Alessio, Sbaraglia Marta, Blandamura Stella, Del Bianco Paola, chiarion sileni vanna, ROSATO ANTONIOJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH11.161
Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemiaForlani Greta, Shallak Mariam, Tedeschi Alessandra, CAVALLARI ILARIA, Marçais Ambroise, Hermine Olivier, Accolla Roberto SHaematologica-The Hematology Journal9.941
Inhibition of SGLT2 Rescues Bone Marrow Cell Traffic for Vascular Repair: Role of Glucose Control and KetogenesisAlbiero Mattia, Tedesco Serena, Amendolagine Francesco Ivan, D’Anna Marianna, Migliozzi Ludovica, Zuccolotto Gaia, ROSATO ANTONIO, Cappellari Roberta, Avogaro Angelo, Fadini Gian PaoloDIABETES9.461
Trastuzumab-lapatinib as neoadjuvant therapy for HER2-positive early breast cancer: Survival analyses of the CHER-Lob trialof the CHER-Lob study team Gruppo, Guarneri Valentina, DIECI MARIA VITTORIA, Griguolo Gaia, Miglietta Federica, GIRARDI FABIO, Bisagni Giancarlo, Generali Daniele G, Cagossi Katia, Sarti Samanta, Frassoldati Antonio, Gianni Lorenzo, Cavanna Luigi, Pinotti Graziella, Musolino Antonino, Piacentini Federico, Cinieri Saverio, Prat Aleix, Conte PierfrancoEUROPEAN JOURNAL OF CANCER9.162
Hematopoietic and Nonhematopoietic p66Shc Differentially Regulates Stem Cell Traffic and Vascular Response to Ischemia in DiabetesAlbiero Mattia, D’Anna Marianna, Bonora Benedetta Maria, Zuccolotto Gaia, ROSATO ANTONIO, Iori Elisabetta, Avogaro Angelo, Fadini Gian PaoloANTIOXIDANTS & REDOX SIGNALING8.401
Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancerGriguolo Gaia, Serna G., Pascual T., Fasani R., Guardia X., Chic N., Paré L., Pernas S., Muñoz M., Oliveira M., Vidal M., Llombart-Cussac A., Cortés J., Galván P., Bermejo B., Martínez N., López R., Morales S., Garau I., Manso L., Alarcón J., Martínez E., Villagrasa P., Prat A., Nuciforo P.npj Precision Oncology8.254
CD80 expression is upregulated by TP53 activation in human cancer epithelial cellsScarpa Melania, Marchiori Chiara, Scarpa Marco, Castagliuolo IgnazioOncoImmunology8.11
GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in TumorsCalì Bianca, Agnellini Andrielly H R, Cioccarelli Chiara, Sanchez-Rodriguez Ricardo, Predonzani Andrea, Toffolo Giulia Ilaria, Viola Antonella, Bronte Vincenzo, Arrigoni Giorgio, Zonta Francesco, Albertoni Laura, Mescoli Claudia, MARIGO ILARIA, Molon BarbaraFrontiers in Immunology7.561
Cancer bio-immunotherapy XVII annual NIBIT (Italian Network for Tumor Biotherapy) meeting, October 11-13 2019, Verona, ItalyBellone Matteo, Bregni Marco, Bronte Vincenzo, Ugel Stefano, Ferrucci Pier Francesco, Di Nicola Massimo, Nisticò Paola, Zuccolotto Gaia, ROSATO ANTONIO, Russo Vincenzo, Sica Antonio, Colombo Mario PCANCER IMMUNOLOGY IMMUNOTHERAPY6.968
Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancerGriguolo Gaia, DIECI MARIA VITTORIA, Paré Laia, miglietta federica , Generali Daniele Giulio, Frassoldati Antonio, Cavanna Luigi, Bisagni Giancarlo, Piacentini Federico, Tagliafico Enrico, Cagossi Katia, Ficarra Guido, Prat Aleix, Conte Pierfranco, Guarneri Valentinanpj Breast Cancer6.923

Source: Biblioteca scientifica IOV

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