Supervisor

Prof. Giuseppe Opocher

Description

The goal of the Cancer Genomics and Big Data research line is to validate methods and pathways that will allow the clinical oncologist to have, at the time of diagnosis, a detailed view of the mutational structure of the tumor, in other words, the molecular footprint of the tumor. The availability of massive parallel sequencing techniques (NGS) will allow the Veneto Institute of Oncology to not only be an active part of the broader ACC Genomics program, initiated by the national IRCCS oncology network Alleanza Contro Cancro (ACC), but also to develop and validate NGS methods for the study of tumor DNA from liquid biopsy or circulating tumor cells.

Background

The notion that cancer is a genetic disease, or rather a disease of the genes, has led to the concept that each tumor is characterized by different mutations or combinations of mutations. The acquisitions in this field have been supported by an acceleration in the availability of technology necessary for DNA analysis, and it is now economically possible to analyze the entire genome of a tumor, paving the way for an intensive use of genetic information in oncology. In fact, several drugs have been developed by virtue of the presence of particular mutations. The challenge before us is to obtain and use complex information, such as the genomic analysis of the tumor, to ensure the most effective therapy for each patient. IOV has accepted this challenge within the ACC genomics program, together with the other members of the IRCCS oncology network.

Rationale

The institute-wide availability of a technology platform for the analysis of tumor genomics, the significant knowledge and experience of IOV in the field of genetics, and the great interest expressed by our clinical oncologists are the indispensable prerequisites for the implementation of this line of research.
Researchers will be able to analyze panels containing all the “actionable” mutations for which present and potential anticancer drugs exist, and all the variants capable of conditioning the efficacy and tolerability of these drugs. This will allow oncologists to choose the most appropriate therapies for that particular tumor and to follow innovative therapeutic protocols. The analysis of tumor genomics will produce a significant amount of data and a formidable informational heritage that will require specific methods of data retention and transmission.

Global goals

  1. To create and validate a path from tumor biopsy to the clinical use of the mutational tumor structure;
  2. To validate the use of the new ACC GENOMICS platform in the study of various tumors, including liquid biopsy;
  3. To validate new platforms for the acquisition and exchange of Big Data.

Expected results

  • the provision of timely and systematic data on the molecular structure of tumors for the appropriate targeted therapy choices;
  • the development of a genomic tool for the study of liquid biopsy able to reveal progressive mutational changes;
  • the identification of new ways to share and transfer Big Data.
Top 15 pubblicazioni 2019 linea 3
TitoloAutoririvistaIF grezzo
Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast CancerGroup SOLAR-1 Study, André Fabrice, Ciruelos Eva, Rubovszky Gabor, Campone Mario, Loibl Sibylle, Rugo Hope S, Iwata Hiroji, Conte Pierfranco, Mayer Ingrid A, Kaufman Bella, Yamashita Toshinari, Lu Yen-Shen, Inoue Kenichi, Takahashi Masato, Pápai Zsuzsanna, Longin Anne-Sophie, Mills David, Wilke Celine, Hirawat Samit, Juric Dejan, Aieta MicheleNEW ENGLAND JOURNAL OF MEDICINE70.67
Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working groupHoeben Bianca A., Carrie Christian, Timmermann Beate, Mandeville Henry C., Gandola Lorenza, Dieckmann Karin, Ramos Albiac Monica, Magelssen Henriette, Lassen-Ramshad Yasmin, Ondrová Barbora, Ajithkumar Thankamma, Alapetite Claire, Balgobind Brian V., Bolle Stephanie, Cameron Alison L., Davila Fajardo Raquel, Dietzsch Stefan, Dumont Lecomte Delphine, van den Heuvel-Eibrink Marry M., Kortmann Rolf D., Laprie Anne, Melchior Patrick, Padovani Laetitia, Rombi Barbara, Scarzello Giovanni, Schwarz Rudolf, Seiersen Klaus, Seravalli Enrica, Thorp Nicola, Whitfield Gillian A., Boterberg Tom, Janssens Geert O.LANCET ONCOLOGY35.386
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancerRobson M E, Tung N, Conte Pierfranco, Im S-A, Senkus E, Xu B, Masuda N, Delaloge S, Li W, Armstrong A, Wu W, Goessl C, Runswick S, Domchek S MANNALS OF ONCOLOGY14.196
HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 BlockadePrat Aleix, Pascual Tomás, De Angelis Carmine, Gutierrez Carolina, Llombart-Cussac Antonio, Wang Tao, Cortés Javier, Rexer Brent, Paré Laia, Forero Andres, Wolff Antonio C, Morales Serafín, Adamo Barbara, Brasó-Maristany Fara, Vidal Maria, Veeraraghavan Jamunarani, Krop Ian, Galván Patricia, Pavlick Anne C, Bermejo Begoña, Izquierdo Miguel, Rodrik-Outmezguine Vanessa, Reis-Filho Jorge S, Hilsenbeck Susan G, Oliveira Mafalda, Dieci Maria Vittoria, Griguolo Gaia, Fasani Roberta, Nuciforo Paolo, Parker Joel S, Conte Pierfranco, Schiff Rachel, Guarneri Valentina, Osborne C Kent, Rimawi Mothaffar FJOURNAL OF THE NATIONAL CANCER INSTITUTE10.211
Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trialDieci Maria Vittoria, Bisagni G, Brandes A, Frassoldati A, Cavanna l, Giotta F, Aieta M, Gebbia V, Musolino A, Garrone O, Donadio M, Rimanti A, Beano A, Zimagni C, Sarti HS, Piacentini F, Danese S, Ferro A, Cagossi K, Sarti S, Gambaro AR, Romito S, Bazan V, Amaducci L, Moretti G, Foschini MP, Balduzzi S, Vicini R, D'Amico R, Griguolo Gaia, Guarneri Valentina, Conte PierfrancoBMC Medicine8.285
MSC-Delivered Soluble TRAIL and Paclitaxel as Novel Combinatory Treatment for Pancreatic AdenocarcinomaRossignoli Filippo, Spano Carlotta, Grisendi Giulia, Foppiani Elisabetta Manuela, Golinelli Giulia, Mastrolia Ilenia, Bestagno Marco, Candini Olivia, Petrachi Tiziana, Recchia Alessandra, Miselli Francesca, Rovesti Giulia, Orsi Giulia, Veronesi Elena, Medici Gregorio, Petocchi Benedetta, Pinelli Massimo, Horwitz Edwin M, Conte Pierfranco, Dominici MassimoTheranostics8.063
EPAC-lung: pooled analysis of circulating tumour cells in advanced non-small cell lung cancerLindsay C R, Blackhall F H, Carmel A, Fernandez-Gutierrez F, Gazzaniga P, Groen H J M, Hiltermann T J N, Krebs M G, Loges S, López-López R, Muinelo-Romay L, Pantel K, Priest L, Riethdorf S, Rossi Elisabetta, Terstappen L, Wikman H, Soria J-C, Farace F, Renehan A, Dive C, Besse B, Michiels SEUROPEAN JOURNAL OF CANCER6.68
Patient-reported outcomes in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer receiving olaparib versus chemotherapy in the OlympiAD trialRobson Mark, Ruddy Kathryn J, Im Seock-Ah, Senkus Elzbieta, Xu Binghe, Domchek Susan M, Masuda Norikazu, Li Wei, Tung Nadine, Armstrong Anne, Delaloge Suzette, Bannister Wendy, Goessl Carsten, Degboe Arnold, Hettle Robert, Conte PierfrancoEUROPEAN JOURNAL OF CANCER6.68
Detection and Prognostic Relevance of Circulating and Disseminated Tumour Cell in Dogs with Metastatic Mammary Carcinoma: A Pilot StudyMarconato Laura, Facchinetti Antonella, Zanardello Claudia, Rossi Elisabetta, Vidotto Riccardo, Capello Katia, Melchiotti Erica, Laganga Paola, Zamarchi Rita, Vascellari MartaCancers6.162
Trastuzumab emtansine with or without pertuzumab versus trastuzumab with taxane for human epidermal growth factor receptor 2-positive advanced breast cancerPerez Edith A, Barrios Carlos, Eiermann Wolfgang, Toi Masakazu, Im Young-Hyuck, Conte Pierfranco, Martin Miguel, Pienkowski Tadeusz, Pivot Xavier B, Burris Howard A, Petersen Jennifer A, De Haas Sanne, Hoersch Silke, Patre Monika, Ellis Paul AnthonyCANCER6.102
A Novel 3D Scaffold for Cell Growth to Asses Electroporation EfficacyDettin Monica, Sieni Elisabetta, Zamuner Annj, Marino Ramona, Sgarbossa Paolo, Lucibello Maria, Tosi Anna Lisa, Keller Flavio, Campana Luca Giovanni, Signori EmanuelaCells5.656
CTCs 2020: Great Expectations or Unreasonable DreamsRossi Elisabetta, Fabbri FrancescoCells5.656
Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relativesGori Stefania, Barberis Massimo, Bella Maria Angela, Buttitta Fiamma, Capoluongo Ettore, Carrera Paola, Colombo Nicoletta, Cortesi Laura, Genuardi Maurizio, Gion Massimo, Guarneri Valentina, Incorvaia Lorena, La Verde Nicla, Lorusso Domenica, Marchetti Antonio, Marchetti Paolo, Normanno Nicola, Pasini Barbara, Pensabene Matilde, Pignata Sandro, Radice Paolo, Ricevuto Enrico, Sapino Anna, Tagliaferri Pierosandro, Tassone Pierfrancesco, Trevisiol Chiara, Truini Mauro, Varesco Liliana, Russo AntonioCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY5.012
The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paperCristofanilli Massimo, Pierga Jean-Yves, Reuben James, Rademaker Alfred, Davis Andrew A, Peeters Dieter J, Fehm Tanja, Nolé Franco, Gisbert-Criado Rafael, Mavroudis Dimitrios, Grisanti Salvatore, Giuliano Mario, Garcia-Saenz Jose A, Stebbing Justin, Caldas Carlos, Gazzaniga Paola, Manso Luis, Zamarchi Rita, de Lascoiti Angela Fernandez, De Mattos-Arruda Leticia, Ignatiadis Michail, Cabel Luc, van Laere Steven J, Meier-Stiegen Franziska, Sandri Maria-Teresa, Vidal-Martinez Jose, Politaki Eleni, Consoli Francesca, Generali Daniele, Cappelletti Maria Rosa, Diaz-Rubio Eduardo, Krell Jonathan, Dawson Sarah-Jane, Raimondi Cristina, Rutten Annemie, Janni Wolfgang, Munzone Elisabetta, Carañana Vicente, Agelaki Sofia, Almici Camillo, Dirix Luc, Solomayer Erich-Franz, Zorzino Laura, Darrigues Lauren, Reis-Filho Jorge S, Gerratana Lorenzo, Michiels Stefan, Bidard François-Clément, Pantel KlausCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY5.012
Maintenance with lanreotide in small-cell lung cancer expressing somatostatine receptors: A multicenter, randomized, phase 3 trialCancer) Italian association FONICAP (Operative National Interdisciplinary Force against Lung, Santo Antonio, Pilotto Sara, Galetta Domenico, Grossi Francesco, Fasola Gianpiero, Romano Gianpiero, Bonanno Laura, Bearz Alessandra, Papi Maximilian, Roca Elisa, Catino Annamaria, Follador Alessandro, Rijavec Erika, Genova Carlo, Petrillo Patrizia, Favaretto Adolfo, Giannone Luciana, Milella Michele, Tortora Giampaolo, Giannarelli Diana, Bria EmilioLUNG CANCER4.599

Source: IOV Scientific library

Top 15 pubblicazioni 2018 linea 3
TitoloAutoriRivistaIF grezzo
Cisplatin-based first-line treatment of elderly patients with advanced non-small-cell lung cancer: Joint analysis of MILES-3 and MILES-4 phase III trialsGridelli C., Morabito A., Cavanna L., Luciani A., Maione P., Bonanno Laura, Filipazzi V., Leo S., Cinieri S., Ciardiello F., Burgio M.A., Bilancia D., Cortinovis D., Rosetti F., Bianco R., Gebbia V., Artioli F., Bordonaro R., Fregoni V., Mencoboni M., Nelli F., Riccardi F., Di Isernia G., Costanzo R., Rocco G., Daniele G., Signoriello S., Piccirillo M.C., Gallo C., Perrone F.JOURNAL OF CLINICAL ONCOLOGY26.36
Paragangliomas arise through an autonomous vasculo-angio-neurogenic program inhibited by imatinibVerginelli Fabio, Perconti Silvia, Vespa Simone, Schiavi Francesca, Prasad Sampath Chandra, Lanuti Paola, Cama Alessandro, Tramontana Lorenzo, Esposito Diana Liberata, Guarnieri Simone, Sheu Artenca, Pantalone Mattia Russel, Florio Rosalba, Morgano Annalisa, Rossi Cosmo, Bologna Giuseppina, Marchisio Marco, D'Argenio Andrea, taschin elisa, Visone Rosa, opocher giuseppe, Veronese Angelo, Paties Carlo T, Rajasekhar Vinagolu K, S¿¿derberg-Naucl¿¿r Cecilia, Sanna Mario, Lotti Lavinia Vittoria, Mariani-Costantini RenatoACTA NEUROPATHOLOGICA15.876
nab-Paclitaxel plus carboplatin or gemcitabine versus gemcitabine plus carboplatin as first-line treatment of patients with triple-negative metastatic breast cancer results from the tnAcity trialtnAcity investigators Gruppo, Yardley D A, Coleman R, Conte Pierfranco, Cortes J, Brufsky A, Shtivelband M, Young R, Bengala C, Ali H, Eakel J, Schneeweiss A, de la Cruz-Merino L, Wilks S, O'Shaughnessy J, Gl¿¿ck S, Li H, Miller J, Barton D, Harbeck NANNALS OF ONCOLOGY13.93
Pathologic Grading of Malignant Pleural Mesothelioma An Evidence-Based ProposalPelosi Giuseppe, Papotti Mauro, Righi Luisella, Rossi Giulio, Ferrero Stefano, Bosari Silvano, Calabrese Fiorella, Kern Izidor, Maisonneuve Patrick, Sonzogni Angelica, Albini Adriana, Harari Sergio, Barbieri Fausto, Capelletto Enrica, Catino Anna Maria, Cavone Domenica, De Palma Angela, Fusco Nicola, Lunardi Francesca, Maiorano Eugenio, Marzullo Andrea, Novello Silvia, Papanikolaou Nikolaos, Pasello Giulia, Pennella Antonio, Pezzuto Federica, Punzi Alessandra, Prisciandaro Elena, Rea Federico, Rosso Lorenzo, Scattone Anna, Serio GabriellaJournal of Thoracic Oncology10.34
Gain-of-function mutations in DNMT3A in patients with paragangliomaRemacha Laura, Curr¿¿s-Freixes Maria, Torres-Ruiz Ra¿¿l, Schiavi Francesca, Torres-P¿¿rez Rafael, Calsina Bruna, Let¿¿n Roc¿¿o, Comino-M¿¿ndez I¿¿aki, Rold¿¿n-Romero Juan M, Montero-Conde Cristina, Santos Mar¿¿a, P¿¿rez Luc¿¿a Inglada, Pita Guillermo, Alonso Mar¿¿a R, Honrado Emiliano, Pedrinaci Susana, Crespo-Facorro Benedicto, Percesepe Antonio, Falcioni Maurizio, Rodr¿¿guez-Perales Sandra, Korpershoek Esther, Ram¿¿n-Maiques Santiago, opocher giuseppe, Rodr¿¿guez-Antona Cristina, Robledo Mercedes, Casc¿¿n AlbertoGENETICS IN MEDICINE9.937
Single tube liquid biopsy for advanced non-small cell lung cancerde Wit Sanne, Rossi Elisabetta, Weber Sabrina, Tamminga Menno, Manicone Mariangela, Swennenhuis Joost F, Groothuis-Oudshoorn Catharina G M, Vidotto Riccardo, Facchinetti Antonella, Zeune Leonie L, Schuuring Ed, Zamarchi Rita, Hiltermann T Jeroen N, Speicher Michael R, Heitzer Ellen, Terstappen Leon W M M, Groen Harry J MINTERNATIONAL JOURNAL OF CANCER7.36
Toward a real liquid biopsy in metastatic breast and prostate cancer Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap)Andree Kiki C, Mentink Anouk, Zeune Leonie L, Terstappen Leon W M M, Stoecklein Nikolas H, Neves Rui P, Driemel Christiane, Lampignano Rita, Yang Liwen, Neubauer Hans, Fehm Tanja, Fischer Johannes C, Rossi Elisabetta, Manicone Mariangela, Basso Umberto, Marson Piero, Zamarchi Rita, Loriot Yohann, Lapierre Valerie, Faugeroux Vincent, Oulhen Marianne, Farace Fran¿¿oise, Fowler Gemma, Sousa Fontes Mariane, Ebbs Berni, Lambros Maryou, Crespo Mateus, Flohr Penny, de Bono Johann SINTERNATIONAL JOURNAL OF CANCER7.36
Prevalence of ALK gene alterations among the spectrum of plexiform spitzoid lesionsSaraggi Deborah, Salmaso Roberto, ZAMUNER CAROLINA, Munari Giada, Lanza Cristiano, Alaibac Mauro Salvatore, Bassetto Franco, Rugge Massimo, montesco maria, Cerroni Lorenzo, Fassan MatteoJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY6.898
BRAF gene copy number and mutant allele frequency correlate with time to progression in metastatic melanoma patients treated with MAPK inhibitorsStagni Camilla, ZAMUNER CAROLINA, Elefanti Lisa, Zanin Tiziana, Del Bianco Paola, Sommariva Antonio, Fabozzi Alessio, Pigozzo Jacopo, mocellin simone, montesco maria, chiarion sileni vanna, De Nicolo Arcangela, Menin ChiaraMOLECULAR CANCER THERAPEUTICS5.365
Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumorsKrauss Tobias, FERRARA ALFONSO MASSIMILIANO, Links Thera P, Wellner Ulrich, Bancos Irina, Kvachenyuk Andrey, Villar G¿¿mez de Las Heras Karina, Yukina Marina Y, Petrov Roman, Bullivant Garrett, von Duecker Laura, Jadhav Swati, Ploeckinger Ursula, Welin Staffan, Schalin-J¿¿ntti Camilla, Gimm Oliver, Pfeifer Marija, Ngeow Joanne, Hasse-Lazar Kornelia, Sans¿¿ Gabriela, Qi Xiaoping, Ugurlu M Umit, Diaz Rene E, Wohllk Nelson, Peczkowska Mariola, Aberle Jens, Louren¿¿o Delmar M, Pereira Maria A A, Fragoso Maria C B V, Hoff Ana O, Almeida Madson Q, Violante Alice H D, Quidute Ana R P, Zhang Zhewei, Recasens M¿¿nica, D¿¿az Luis Robles, Kunavisarut Tada, Wannachalee Taweesak, Sirinvaravong Sirinart, Jonasch Eric, Grozinsky-Glasberg Simona, Fraenkel Merav, Beltsevich Dmitry, Egorov Viacheslav I, Bausch Dirk, Schott Matthias, Tiling Nikolaus, Pennelli Gianmaria, Zschiedrich Stefan, D¿¿rr Roland, Ruf Juri, Denecke Timm, Link Karl-Heinrich, Zovato Stefania, von Dobschuetz Ernst, Yaremchuk Svetlana, Amthauer Holger, Makay ¿¿zer, Patocs Attila, Walz Martin K, Huber Tobias B, Seufert Jochen, Hellman Per, Kim Raymond H, Kuchinskaya Ekaterina, Schiavi Francesca, Malinoc Angelica, Reisch Nicole, Jarzab Barbara, Barontini Marta, Januszewicz Andrzej, Shah Nalini, Young William F, opocher giuseppe, Eng Charis, Neumann Hartmut P H, Bausch BirkeENDOCRINE-RELATED CANCER5.331
65 YEARS OF THE DOUBLE HELIX Genetics informs precision practice in the diagnosis and management of pheochromocytomaNeumann Hartmut P, Young William F, Krauss Tobias, Bayley Jean-Pierre, Schiavi Francesca, opocher giuseppe, Boedeker Carsten C, Tirosh Amit, Castinetti Frederic, Ruf Juri, Beltsevich Dmitry, Walz Martin, Groeben Harald-Thomas, von Dobschuetz Ernst, Gimm Oliver, Wohllk Nelson, Pfeifer Marija, Louren¿¿o Delmar M, Peczkowska Mariola, Patocs Attila, Ngeow Joanne, Makay ¿¿zer, Shah Nalini S, Tischler Arthur, Leijon Helena, Pennelli Gianmaria, Villar G¿¿mez de Las Heras Karina, Links Thera P, Bausch Birke, Eng CharisENDOCRINE-RELATED CANCER5.331
Therapeutic perspectives for brain metastases in non-oncogene addicted non-small cell lung cancer (NSCLC) Towards a less dismal future?Frega Stefano, Bonanno Laura, Guarneri Valentina, Conte Pierfranco, Pasello GiuliaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY4.495
Activity of EGFR TKIs in Caucasian Patients With NSCLC Harboring Potentially Sensitive Uncommon EGFR MutationsPassaro A., Prelaj A., Bonanno Laura, Tiseo M., Tuzi A., Proto C., Chiari R., Rocco D., Genova C., Sini C., Cortinovis D., Pilotto S., Landi L., Bennati C., Camerini A., Toschi L., Putzu C., Cerea G., Spitaleri G., Cappuzzo F., de Marinis F.Clinical Lung Cancer4.204
RELEVENT Trial Phase II Trial of Ramucirumab, Carboplatin, and Paclitaxel in Previously Untreated Thymic Carcinoma/B3 Thymoma With Area of CarcinomaImbimbo Martina, Vitali Milena, Fabbri Alessandra, Ottaviano Margaret, Pasello Giulia, Petrini Iacopo, Palmieri Giovannella, Berardi Rossana, Zucali Paolo, Ganzinelli Monica, Marabese Mirko, Broggini Massimo, Marino Mirella, Trama Annalisa, Rulli Eliana, Hollander Lital, Pruneri Giancarlo, Torri Valter, Garassino Marina ChiaraClinical Lung Cancer4.204
An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA projectPelizzari Giacomo, Arpino Grazia, Biganzoli Laura, Cinieri Saverio, De Laurentiis Michelino, Di Leo Angelo, Guarneri Valentina, Marchetti P, Puglisi FBMC CANCER3.288

Source: IOV Scientific library