LINE 5 – new organizational models: pdta (diagnostic and therapeutic care pathways) and indicators

LINE 5 – new organizational models: pdta (diagnostic and therapeutic care pathways) and indicators

Supervisor

Prof. PierFranco Conte

Description

The main objective in the drafting of the Oncology Network’s PDTA (DGR 2067/2013) is to ensure promptness, adequate levels and continuity of care throughout the care pathway: from the moment the patient enters the pathway, to the multidisciplinary evaluation of his or her tumor, until complete remission or end of life.
The preservation of a respectable quality of life, from the early stages onward, the provision of adequate support for the patient and his or her family, and the protection of the dignity and autonomy of cancer patients are an integral part of the PDTA.

Background

The IOV is the hub of the hospital and territorial oncology network of the Veneto Region (ROV). It coordinates regional oncology care in close harmony with all hospital companies of the Veneto region. PDTA for various types of cancers have been defined and shared among the hospitals.
In the context of demand management, an organizational model that puts the cancer patient at the center and is able to respond to ethical and social needs is necessary to reduce drop-out from the defined care pathways.

Rationale

Monitoring of the PDTA through specific performance indicators makes it possible to analyze cancer care across the network. It becomes, therefore, of strategic importance to identify indicators of performance within the Institute that can also be expanded to the regional level. This will make it possible to have quantitative evidence for business and healthcare planning of the Institute in order to verify the appropriateness, continuity and uniformity of care, and the quality of the services offered.
Analysis of performance indicators will allow on-site verification of improvements introduced by the PDTAs and will help guide decisions. Indicators are today identified with information obtained from the current information flows (specialist care, hospitalization, pharmaceutical, home care, regional mortality register), appropriately integrated with record linkage techniques.

Global goals

The overall goal of this research line is to evaluate the compliance to ROV PDTA indicators in patients treated at the Veneto Institute of Oncology in the various care pathways. In particular:

  1. monitoring of adherence to performance indicators;
  2. implementation of internal audits;
  3. analysis of any corrective systems.

Expected results

  • The development of an application that will provide direct access to structure and process indicator data that can be extracted from regional information flows to verify the true state of cancer patient care as defined by the various PDTAs of the Veneto Oncology Network.
  • Measurable activities used as indicators to verify results:
    • number of admissions for surgery;
    • waiting times to begin chemotherapy / post-intervention radiotherapy;
    • chemotherapy in the last 30 days of life;
    • inappropriate diagnostic tests (TAC, Magnetic Resonance, PET, etc);
    • number of audits developed.

Top 15 pubblicazioni Linea 5 anno 2020
TitoloAutori/AutriciRivistaIF grezzo
Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer.Investigators ADAURA, Wu Yi-Long, Tsuboi Masahiro, He Jie, John Thomas, Grohe Christian, Majem Margarita, Goldman Jonathan W, Laktionov Konstantin, Kim Sang-We, Kato Terufumi, Vu Huu-Vinh, Lu Shun, Lee Kye-Young, Akewanlop Charuwan, Yu Chong-Jen, de Marinis Filippo, Bonanno Laura, Domine Manuel, Shepherd Frances A, Zeng Lingmin, Hodge Rachel, Atasoy Ajlan, Rukazenkov Yuri, Herbst Roy S, Galetta DomenicoNEW ENGLAND JOURNAL OF MEDICINE74.699
Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping MutationsPaik Paul K, Felip Enriqueta, Veillon Remi, Sakai Hiroshi, Cortot Alexis B, Garassino Marina C, Mazieres Julien, Viteri Santiago, Senellart Helene, Van Meerbeeck Jan, Raskin Jo, Reinmuth Niels, Conte Pierfranco, Kowalski Dariusz, Cho Byoung Chul, Patel Jyoti D, Horn Leora, Griesinger Frank, Han Ji-Youn, Kim Young-Chul, Chang Gee-Chen, Tsai Chen-Liang, Yang James C-H, Chen Yuh-Min, Smit Egbert F, van der Wekken Anthonie J, Kato Terufumi, Juraeva Dilafruz, Stroh Christopher, Bruns Rolf, Straub Josef, Johne Andreas, Scheele Jürgen, Heymach John V, Le XiuningNEW ENGLAND JOURNAL OF MEDICINE74.699
Cancer and COVID-19: what do we really know?Poortmans Philip M., Guarneri Valentina, Cardoso Maria JoãoLANCET60.39
COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort studyInvestigators TERAVOLT, Garassino Marina Chiara, Whisenant Jennifer G., Huang Li Ching, Trama Annalisa, Torri Valter, Agustoni Francesco, Baena Javier, Banna Giuseppe, Berardi Rossana, Bettini Anna Cecilia, Bria Emilio, Brighenti Matteo, Cadranel Jacques, De Toma Alessandro, Chini Claudio, Cortellini Alessio, Felip Enriqueta, Finocchiaro Giovanna, Garrido Pilar, Genova Carlo, Giusti Raffaele, Gregorc Vanesa, Grossi Francesco, Grosso Federica, Intagliata Salvatore, La Verde Nicla, Liu Stephen V., Mazieres Julien, Mercadante Edoardo, Michielin Olivier, Minuti Gabriele, Moro-Sibilot Denis, Pasello Giulia, Passaro Antonio, Scotti Vieri, Solli Piergiorgio, Stroppa Elisa, Tiseo Marcello, Viscardi Giuseppe, Voltolini Luca, Wu Yi Long, Zai Silvia, Pancaldi Vera, Dingemans Anne Marie, Van Meerbeeck Jan, Barlesi Fabrice, Wakelee Heather, Peters Solange, Horn LeoraLANCET ONCOLOGY33.752
Psychometric properties of the updated EORTC module for assessing quality of life in patients with lung cancer (QLQ-LC29): an international, observational field studyGroup European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life, Koller Michael, Shamieh Omar, Hjermstad Marianne J, Hornslien Kjersti, Young Teresa, Chalk Tara, Ioannidis Georgios, Harle Amelie, Johnson Colin D, Tomaszewski Krzysztof A, Serpentini Samantha, Pinto Monica, van der Weijst Lotte, Janssens Annelies, Morag Ofir, Chie Wei-Chu, Arraras Juan I, Pompili Cecilia, Jungraithmayr Wolfgang, Hechtner Marlene, Katsochi Despina, Müller Karolina, Gräfenstein Laura, Schulz Christian, Bottomley AndrewLANCET ONCOLOGY33.752
Incidence of SARS-CoV-2 Infection Among Patients Undergoing Active Antitumor Treatment in ItalyAschele Carlo, Negru Maria Emanuela, Pastorino Alessandro, Cavanna Luigi, zagonel vittorina, Barone-Adesi Francesco, Blasi LivioJAMA Oncology24.799
Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: final overall survival results from SOLAR-1André F., Ciruelos E. M., Juric D., Loibl S., Campone M., Mayer I. A., Rubovszky G., Yamashita T., Kaufman B., Lu Y. S., Inoue K., Pápai Z., Takahashi M., Ghaznawi F., Mills D., Kaper M., Miller M., Conte Pierfranco, Iwata H., Rugo H. S.ANNALS OF ONCOLOGY18.274
An international update of the EORTC questionnaire for assessing quality of life in breast cancer patients: EORTC QLQ-BR45EORTC Quality of Life Group and Breast Cancer Group Gruppo, Bjelic-Radisic V., Cardoso F., Cameron D., Brain E., Kuljanic K., da Costa R. A., Conroy T., Inwald E. C., Serpentini Samantha, Pinto M., Weis J., Morag O., Lindviksmoen Astrup G., Tomaszweksi K. A., Pogoda K., Sinai P., Sprangers M., Aaronson N., Velikova G., Greimel E., Arraras J., Bottomley A., Bleiker Eveline, Bliem Brigitte, Chie Weichu, Creutzberg Carien, Deville Valerie, Duhoux Francois, Eilf Kirsten, Hartup Sue, Koller Michael, Nagele Eva, Nicolatou-Galitis Ourania, Oberguggenberger Anne, Schmalz Claudia, Winters ZoeANNALS OF ONCOLOGY18.274
Time course and management of key adverse events during the randomized phase III SOLAR-1 study of PI3K inhibitor alpelisib plus fulvestrant in patients with HR-positive advanced breast cancerRugo H S, André F, Yamashita T, Cerda H, Toledano I, Stemmer S M, Jurado J C, Juric D, Mayer I, Ciruelos E M, Iwata H, Conte Pierfranco, Campone M, Wilke C, Mills D, Lteif A, Miller M, Gaudenzi F, Loibl SANNALS OF ONCOLOGY18.274
A Randomized Open-Label Phase III Trial Evaluating the Addition of Denosumab to Standard First-Line Treatment in Advanced NSCLC: The European Thoracic Oncology Platform (ETOP) and European Organisation for Research and Treatment of Cancer (EORTC) SPLENDOUR TrialPeters Solange, Danson Sarah, Hasan Baktiar, Dafni Urania, Reinmuth Niels, Majem Margarita, Tournoy Kurt G, Mark Michael T, Pless Miklos, Cobo Manuel, Rodriguez-Abreu Delvys, Falchero Lionel, Moran Teresa, Ortega Granados Ana Laura, Monnet Isabelle, Mohorcic Katja, Sureda Bartomeu Massutí, Betticher Daniel, Demedts Ingel, Macias Jose Antionio, Cuffe Sinead, Luciani Andrea, Sanchez Jose Garcia, Curioni-Fontecedro Alessandra, Gautschi Oliver, Price Gillian, Coate Linda, von Moos Roger, Zielinski Christoph, Provencio Mariano, Menis Jessica, Ruepp Barbara, Pochesci Alessia, Roschitzki-Voser Heidi, Besse Benjamin, Rabaglio Manuela, O’Brien Mary E R, Stahel Rolf AJOURNAL OF THORACIC ONCOLOGY 13.357
Checkpoint Inhibitors in SCLC: How Much Can We Trust in Randomized Cohorts of Phase I/II Trials?Menis Jessica, Reck MartinJOURNAL OF THORACIC ONCOLOGY 13.357
Combination of Immunotherapy and Radiotherapy- The Next Magic Step in the Management of Lung Cancer?Hendriks Lizza E.L., Menis Jessica, De Ruysscher Dirk K.M., Reck MartinJOURNAL OF THORACIC ONCOLOGY 13.357
Overall Survival of CDK4/6-Inhibitor-Based Treatments in Clinically Relevant Subgroups of Metastatic Breast Cancer: Systematic Review and Meta-AnalysisSchettini Francesco, Giudici Fabiola, Giuliano Mario, Cristofanilli Massimo, Arpino Grazia, Del Mastro Lucia, Puglisi Fabio, De Placido Sabino, Paris Ida, De Placido Pietro, Venturini Sergio, De Laurentis Michelino, Conte Pierfranco, Juric Dejan, Llombart-Cussac Antonio, Pusztai Lajos, Prat Aleix, Jerusalem Guy, Di Leo Angelo, Generali DanieleJOURNAL OF THE NATIONAL CANCER INSTITUTE11.577
Real world data in the era of Immune Checkpoint Inhibitors (ICIs): Increasing evidence and future applications in lung cancerPasello Giulia, Pavan Alberto, Attili Ilaria, Bortolami Alberto, Bonanno Laura, Menis Jessica, Conte Pierfranco, Guarneri ValentinaCANCER TREATMENT REVIEWS8.885
Repeat Screening Outcomes with Digital Breast Tomosynthesis Plus Synthetic Mammography for Breast Cancer Detection: Results from the Prospective Verona Pilot StudyCaumo Francesca, Montemezzi Stefania, Romanucci Giovanna, Brunelli Silvia, Bricolo Paola, Cugola Loredana, Gennaro Gisella MariaRADIOLOGY7.931

Source: Biblioteca scientifica IOV

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Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD)Schadendorf Dirk, Hauschild Axel, Santinami Mario, Atkinson Victoria, Mandalà Mario, chiarion sileni vanna, Larkin James, Nyakas Marta, Dutriaux Caroline, Haydon Andrew, Robert Caroline, Mortier Laurent, Lesimple Thierry, Plummer Ruth, Schachter Jacob, Dasgupta Kohinoor, Manson Stephanie, Koruth Roy, Mookerjee Bijoyesh, Kefford Richard, Dummer Reinhard, Kirkwood John M., Long Georgina V.LANCET ONCOLOGY35.386
Treatment duration of checkpoint inhibitors for NSCLCRemon Jordi, Menis Jessica, Aspeslagh Sandrine, Besse BenjaminLancet Respiratory Medicine22.992
Risk-reducing medications for primary breast cancer: a network meta-analysismocellin simone, Goodwin Annabel, Pasquali SandroCochrane Database of Systematic Reviews7.755
Uveal Melanoma Biopsy: A ReviewFrizziero Luisa, Midena Edoardo, Trainiti Sara, Londei Davide, Bonaldi Laura, Bini Silvia, Bini Silvia, Parrozzani RaffaeleCancers6.162
The Prognostic Nutritional Index Predicts Survival and Response to First-Line Chemotherapy in Advanced Biliary CancerSalati M, Filippi R, Vivaldi C, Caputo F, Leone F, Salani F, Cerma K, Aglietta M, Fornaro L, Sperti E, Di Maio M, Ortega C, Fenocchio E, Lombardi P, Cagnazzo C, Depetris Ilaria, Gelsomino F, Spallanzani A, Santini D, Silvestris N, Aprile G, Roviello G, Scartozzi M, Cascinu S, Casadei-Gardini ALIVER INTERNATIONAL5.542
From Diagnostic-Therapeutic Pathways to Real-World Data: A Multicenter Prospective Study on Upfront Treatment for EGFR-Positive Non-Small Cell Lung Cancer (MOST Study)Pasello Giulia, Vicario Giovanni, Zustovich Fable, Oniga Francesco, Gori Stefania, Rosetti Francesco, Bonetti Andrea, Favaretto Adolfo, Toso Silvia, Redelotti Roberta, Santo Antonio, Bernardi Daniele, Giovanis Petros, Oliani Cristina, Calvetti Lorenzo, Gatti Carlo, Palazzolo Giovanni, Baretta Zora, Bortolami Alberto, Bonanno Laura, Basso Marco, Menis Jessica, Corte Donatella Da, Frega Stefano, Guarneri Valentina, Conte Pierfranco, ON BEHALF OF VENETO ONCOLOGY NETWORKONCOLOGIST5.252
Real-World Evidence in Oncology: Opportunities and LimitationsDi Maio Massimo, Perrone Francesco, Conte PierfrancoONCOLOGIST5.252
Heterogeneous Tumor Features and Treatment Outcome Between Males and Females With Lung Cancer (LC): Do Gender and Sex Matter?Frega Stefano, Dal Maso Alessandro, Ferro Alessandra, Bonanno Laura, Conte Pierfranco, Pasello GiuliaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY5.012
Treatment of advanced non-small-cell lung cancer: The 2019 AIOM (Italian Association of Medical Oncology) clinical practice guidelinesPassiglia F, Pilotto S, Facchinetti F, Bertolaccini L, Del Re M, Ferrara R, Franchina T, Malapelle U, Menis Jessica, Passaro A, Ramella S, Rossi G, Trisolini R, Novello SCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY5.012
Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and PerspectivesCavallari Ilaria, Urso Loredana, Sharova Evgeniya, Pasello Giulia, Ciminale VincenzoFrontiers in Oncology4.137
New Paradigm for Stage III Melanoma: From Surgery to Adjuvant TreatmentAscierto Paolo Antonio, Borgognoni Lorenzo, Botti Gerardo, Guida Michele, Marchetti Paolo, mocellin simone, Muto Paolo, Palmieri Giuseppe, Patuzzo Roberto, Quaglino Pietro, Stanganelli Ignazio, Caracò CorradoJournal of Translational Medicine4.098
Colic and Rectal Tumors With Peritoneal Metastases Treated With Cytoreductive Surgery and HIPEC: One Homogeneous Condition or Two Different Diseases? A Systematic Review and Meta-AnalysisTonello Marco, Sommariva Antonio, Pirozzolo Giovanni, Mattara Genny, pilati pierluigiEJSO3.379
Nutritional Therapy in Cancer Patients Receiving Chemoradiotherapy: Should We Need Stronger Recommendations to Act for Improving Outcomes?Cotogni Paolo, Pedrazzoli Paolo, De Waele Elisabeth, Aprile Giuseppe, Farina Gabriella, Stragliotto Silvia, De Lorenzo Francesco, Caccialanza RiccardoJournal of Cancer3.182
Health-related Quality of Life in the Phase III LUME-Colon 1 Study: Comparison and Interpretation of Results From EORTC QLQ-C30 AnalysesLenz Heinz Josef, Argiles Guillem, Yoshino Takayuki, Lonardi Sara, Falcone Alfredo, Limón María Luisa, Sobrero Alberto, Hastedt Claudia, Peil Barbara, Voss Florian, Griebsch Ingolf, Van Cutsem EricClinical Colorectal Cancer3.176
Prevalence of Pain in Patients With Cancer Aged 70 Years or Older: A Prospective Observational StudyBrunello Antonella, AHCENE DJABALLAH SELMA, Lettiero Annunziata, Tierno Giuseppina, Fiduccia Pasquale, Guglieri Irene, Dadduzio Vincenzo, Maruzzo Marco, Schiavon Stefania, Lonardi Sara, zagonel vittorinaJournal of Geriatric Oncology3.164

Source: Biblioteca scientifica IOV

Top 15 pubblicazioni 2021 linea 5
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Benefits and Harms of Lung Cancer Screening by Chest Computed Tomography: A Systematic Review and Meta-AnalysisPassiglia Francesco, Cinquini Michela, Bertolaccini Luca, Del Re Marzia, Facchinetti Francesco, Ferrara Roberto, Franchina Tindara, Larici Anna R, Malapelle Umberto, Menis Jessica, Passaro Antonio, Pilotto Sara, Ramella Sara, Rossi Giulio, Trisolini Rocco, Novello SilviaJOURNAL OF CLINICAL ONCOLOGY44.544
[18F]-Fluciclovine PET/CT for preoperative nodal staging in high-risk primary prostate cancer: final results of a prospective trialZanoni Lucia, Bianchi Lorenzo, Nanni Cristina, Pultrone Cristian, Giunchi Francesca, Bossert Irene, Matti Antonella, Schiavina Riccardo, Fiorentino Michelangelo, Romagnoli Daniele, Fonti Cristina, Lodi Filippo, D’Errico Antonietta, Brunocilla Eugenio, PORRECA ANGELO, Fanti StefanoEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING9.236
Epidemiology and clinical course of severe acute respiratory syndrome coronavirus 2 infection in cancer patients in the Veneto Oncology Network: The Rete Oncologica Veneta covID19 studyVeneto Oncology Network Gruppo, Guarneri Valentina, Bassan Franco, zagonel vittorina, Milella Michele, Zaninelli Marta, Cattelan Anna Maria, Vianello Andrea, Gori Stefania, Aprile Giuseppe, Azzarello Giuseppe, Chiari Rita, Favaretto Adolfo, Oliani Cristina, Scola Annamaria, Pastorelli Davide, Mandarà Marta, Zustovich Fable, Bernardi Daniele, chiarion sileni vanna, Morandi Paolo, Toso Silvia, Di Liso Elisabetta, Ziampiri Stamatia, Caccese Mario, Zampiva Ilaria, Puccetti Oliviero, Celestino Michele, DIECI MARIA VITTORIA, Conte PierfrancoEUROPEAN JOURNAL OF CANCER9.162
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Source: Biblioteca scientifica IOV

Last modified: 18/02/2022 09:25

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