From 2000-2006, Tosello Valeria has been involved in several project focused on tumor immunology first in the laboratory of Prof. Alberto Amadori and Prof. Paola Zanovello at the University of Padova and subsequently, in the laboratory of Prof. Danila Valmori at Columbia University in New York City. She has worked on several interesting topics in the tumor immunology field such as studying the role of IFNa on dendritic cell differentiantion and antigen presentation (Tosello V., Eur J Immunol. 2009, Jan) and the characterization of naïve and memory T-regulatory cells (Tosello V., Clin Immunol. 2008 Mar).
In 2006, she subsequently moved to the laboratory of Adolfo Ferrando, at the Institute for Cancer Genetics at Columbia University, where she developed a strong background on the cellular and molecular biology of T-cell acute lymphoblastic leukemia (T-ALL). She contributed to several works centered on drug resistance and targeted therapies, with particular respect to NOTCH1 signaling (Sulis ML., Blood. 2008 Aug; Real Pj, Nat Med. 2009 Jan; Herranz D., Nat Med. 2015 Oct). She identified somatic mutations in WT1 tumor suppressor gene in T-ALL (Tosello V., Blood. 2009 Jul). She is still involved on studies focused on the role of WT1 tumor suppressor gene in acute myeloid leukemia (AML) (Rampal R., Cell Rep. 2014 Dec) and T-ALL. Her research interest is focused on altered signaling pathway on T-ALL which involves NOTCH1 oncogenic pathway (Tosello V., Oncotarget 2016, June; Tosello V., Leukemia 2016 April) and metabolism.
Immunology and Molecular Oncology Unit
– Department of Translational Oncology and Health Services, IOV-IRCCS
- Curriculum Vitae
- phone: ++39 049 821 5895
- fax: ++39 049 807 2854
- ORCID: 0000-0001-9560-340X