The Immunology and Molecular Oncology unit develops, standardizes and performs molecular investigations and innovative approaches that enable the IOV to offer advanced diagnostic services, follow-up and personalized therapies to patients with solid and haematological malignancies.

The unit is also active in secondary prevention programs for cervical carcinoma and provides services for the definition of the hereditary risk of some cancers.
Thanks to the skills developed, the Immunology and Molecular Oncology Unit receives requests for services from many healthcare facilities in the Veneto and other regions.

The diagnostic activity is divided as follows:

  • cytogenetic and molecular analysis for the diagnosis, characterization and monitoring of neoplastic hemolymphopoietic disorders (genetic and chromosomal rearrangements, lymphocytic clonality);
  • molecular analysis for the research of prognostic and predictive response markers, aimed at the personalization of therapy in solid tumors (breast, lung, colorectal, melanoma, brain neoplasms, GIST);
  • analysis of the BRCA1 and BRCA2 genes for the genetic predisposition to the hereditary tumors of the breast and of the ovary, and of the CDKN2A gene for the genetic predisposition to melanoma, following oncogenetic counseling;
  • tumor virology analysis (HPV, EBV, HHV8, HTLV virus);
  • research, quantitative analysis and characterization of HIV-1 and HIV-2 viruses in particular cohorts of subjects at high risk, with particular reference to pediatric patients;
  • pharmacogenetic analysis for the study of genetic factors that influence the therapeutic response;
  • immunology analysis of tumors.

The unit uses highly sensitive technologies and, thanks to the combined use of complementary methods, allows the highlighting of molecular alterations of different natures, such as point alterations but also large genomic rearrangements.
These activities are included in a certified process and subject to periodic external quality audits, in compliance with the indications on genetic tests in oncology issued by scientific societies and other appointed bodies.

Innovation as a vocation

The Unit’s vocation is the development, standardization and execution of molecular investigations and innovative approaches that allow advanced diagnostics, follow-up and personalized therapy of patients with solid and hematological malignancies.

This primary objective is essentially pursued through:

  • understanding and respecting the needs and expectations of particularly sensitive users such as cancer patients and their families;
  • the continuous symbiosis between research and assistance, pursued in the belief that good clinical practice cannot be dissociated from good clinical and preclinical research;
  • the continuous updating of personnel on the most important topics in the fields of immunology and oncology, through the attendance of seminars, courses and congresses as well as close and constant collaborations with international reference laboratories;
  • the meticulous training of technical staff and observance of rigorous executive protocols in the various laboratory techniques, as well as of the most stringent safety rules for the protection of operators from biological hazards;
  • close collaboration with Paduan and Veneto oncologists and onco-hematologists, with a view to spreading the most advanced diagnostics throughout the territory;
  • synergy with the University and Padua City Hospitals, with a view of implementation of their respective competences.

Direttore F.F.

Dott.ssa Annarosa del Mistro

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