UOSD Experimental and translational basic oncology

The UOSD Experimental and Translational Basic Oncology carries out research and molecular diagnostics in the IOV laboratories located in the Research Tower and at the Busonera Hospital in Padua. The main activity of the laboratories is the characterization of molecular alterations with a predictive value of response in the plasma or tissue of patients with lung cancer (liquid biopsy).

Tests performed:

• Search for EGFR gene mutations
• PIK3CA gene mutation search test and NTRK1-3, ALK, ROS1, RET, MET gene alteration test
• Comprehensive Genomic Profiling (CGP)
• Search for somatic mutations

Starting from 2018, new state-of-the-art sequencing methods (NGS) have been adopted in these laboratories which, alongside the classical methods of molecular genetics, allow to improve the diagnostic activity and to deepen the understanding in the field of cancer genomics. The quality of the aforementioned analyzes is monitored and guaranteed through the use of internal quality controls and participation in national and international (EMQN) external quality assessment programs (VEQ).

The Unit actively participates in the regional Molecular Tumor Board and in GOM breast, melanoma and sarcomas.